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Gene: Pax2 (paired box 2) Mus musculus
Symbol: Pax2
Name: paired box 2
Description: Exhibits C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including nervous system development; regulation of kidney development; and urogenital system development. Localizes to the nucleus and protein-DNA complex. Used to study renal coloboma syndrome. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7 and renal coloboma syndrome. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; sensory organ; and tibia. Orthologous to human PAX2 (paired box 2); INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Opdc; optic disc coloboma; paired box gene 2; paired box protein Pax-2; Pax-2
Homo sapiens (human) : PAX2 (paired box 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pax2 (paired box 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pax2 (paired box 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PAX2 (paired box 2)
Canis lupus familiaris (dog) : PAX2 (paired box 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pax2 (paired box 2)
Sus scrofa (pig) : PAX2 (paired box 2)
Chlorocebus sabaeus (African green monkey) : PAX2 (paired box 2)
Heterocephalus glaber (naked mole-rat) : Pax2 (paired box 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1944,756,045 - 44,837,871 (+)EnsemblGRCm38mm10GRCm38
GRCm381944,746,601 - 44,838,269 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371944,831,884 - 44,910,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv361944,810,705 - 44,889,338 (+)NCBImm8
Celera1945,528,146 - 45,605,640 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Pax2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313674
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.