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Gene: ZMPSTE24 (zinc metallopeptidase STE24) Homo sapiens
Symbol: ZMPSTE24
Name: zinc metallopeptidase STE24
CRRD ID: 1313677
Description: Predicted to have metalloendopeptidase activity. Involved in regulation of defense response to virus. Localizes to protein-containing complex. Implicated in connective tissue disease and lethal restrictive dermopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAAX prenyl protease 1 homolog; FACE-1; FACE1; farnesylated proteins-converting enzyme 1; farnesylated-proteins converting enzyme 1; FLJ14968; HGPS; Hutchinson-Gilford progeria syndrome; prenyl protein-specific endoprotease 1; PRO1; STE24; Ste24p; zinc metallopeptidase STE24 homolog; zinc metalloproteinase Ste24 homolog
Mus musculus (house mouse) : Zmpste24 (zinc metallopeptidase, STE24)  MGI  Alliance
Rattus norvegicus (Norway rat) : Zmpste24 (zinc metallopeptidase STE24)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zmpste24 (zinc metallopeptidase STE24)
Pan paniscus (bonobo/pygmy chimpanzee) : ZMPSTE24 (zinc metallopeptidase STE24)
Canis lupus familiaris (dog) : ZMPSTE24 (zinc metallopeptidase STE24)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zmpste24 (zinc metallopeptidase STE24)
Sus scrofa (pig) : ZMPSTE24 (zinc metallopeptidase STE24)
Chlorocebus sabaeus (African green monkey) : ZMPSTE24 (zinc metallopeptidase STE24)
Heterocephalus glaber (naked mole-rat) : Zmpste24 (zinc metallopeptidase STE24)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl140,258,041 - 40,294,180 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl140,258,236 - 40,294,180 (+)EnsemblGRCh38hg38GRCh38
GRCh38140,258,078 - 40,294,180 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37140,723,722 - 40,759,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,496,320 - 40,532,443 (+)NCBINCBI36hg18NCBI36
Build 34140,392,871 - 40,428,944NCBI
Celera139,006,122 - 39,042,251 (+)NCBI
Cytogenetic Map1p34.2NCBI
HuRef138,842,523 - 38,878,354 (+)NCBIHuRef
CHM1_1140,839,331 - 40,875,788 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ZMPSTE24
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313677
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.