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Gene: Zmpste24 (zinc metallopeptidase, STE24) Mus musculus
Symbol: Zmpste24
Name: zinc metallopeptidase, STE24
CRRD ID: 1313678
Description: Exhibits double-stranded DNA binding activity and metalloendopeptidase activity. Involved in several processes, including animal organ development; chromosome organization; and regulation of intracellular signal transduction. Localizes to membrane and nuclear envelope. Is expressed in early conceptus. Used to study Emery-Dreifuss muscular dystrophy; familial partial lipodystrophy; and progeria. Human ortholog(s) of this gene implicated in connective tissue disease and lethal restrictive dermopathy. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A530043O15Rik; CAAX prenyl protease 1 homolog; D030046F19; Face-1; FACE1; farnesylated proteins-converting enzyme 1; farnesylated-proteins converting enzyme 1; MADB; prenyl protein-specific endoprotease 1; STE24; Ste24p; zinc metallopeptidase STE24; zinc metallopeptidase, STE24 homolog; zinc metalloproteinase Ste24 homolog; zinc metalloproteinase, STE24 homolog
Homo sapiens (human) : ZMPSTE24 (zinc metallopeptidase STE24)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Zmpste24 (zinc metallopeptidase STE24)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zmpste24 (zinc metallopeptidase STE24)
Pan paniscus (bonobo/pygmy chimpanzee) : ZMPSTE24 (zinc metallopeptidase STE24)
Canis lupus familiaris (dog) : ZMPSTE24 (zinc metallopeptidase STE24)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zmpste24 (zinc metallopeptidase STE24)
Sus scrofa (pig) : ZMPSTE24 (zinc metallopeptidase STE24)
Chlorocebus sabaeus (African green monkey) : ZMPSTE24 (zinc metallopeptidase STE24)
Heterocephalus glaber (naked mole-rat) : Zmpste24 (zinc metallopeptidase STE24)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl4121,059,237 - 121,098,241 (-)EnsemblGRCm38mm10GRCm38
GRCm384121,059,237 - 121,098,249 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374120,731,843 - 120,770,848 (-)NCBIGRCm37mm9NCBIm37
MGSCv364120,556,873 - 120,595,878 (-)NCBImm8
Celera4119,770,178 - 119,809,143 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Zmpste24
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313678
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.