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Gene: Rag2 (recombination activating gene 2) Mus musculus
Symbol: Rag2
Name: recombination activating gene 2
Description: Exhibits several functions, including methylated histone binding activity; phosphatidylinositol phosphate binding activity; and zinc ion binding activity. Involved in several processes, including B cell homeostatic proliferation; immune system development; and positive regulation of organ growth. Predicted to localize to DNA recombinase complex. Is expressed in gut; hemolymphoid system; and liver. Used to study Omenn syndrome and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in Omenn syndrome; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2); PARTICIPATES IN histone modification pathway; primary immunodeficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Rag-2; recombinase activating gene 2; recombination activating protein 2; V(D)J recombination-activating protein 2
Homo sapiens (human) : RAG2 (recombination activating 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rag2 (recombination activating 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rag2 (recombination activating 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RAG2 (recombination activating 2)
Canis lupus familiaris (dog) : RAG2 (recombination activating 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rag2 (recombination activating 2)
Sus scrofa (pig) : RAG2 (recombination activating 2)
Chlorocebus sabaeus (African green monkey) : RAG2 (recombination activating 2)
Heterocephalus glaber (naked mole-rat) : Rag2 (recombination activating 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2101,624,718 - 101,632,529 (+)EnsemblGRCm38mm10GRCm38
GRCm382101,624,712 - 101,632,528 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372101,464,905 - 101,472,685 (+)NCBIGRCm37mm9NCBIm37
MGSCv362101,425,587 - 101,433,367 (+)NCBImm8
Celera2102,849,742 - 102,857,519 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map253.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rag2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313707
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.