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Gene: Rag2 (recombination activating gene 2) Mus musculus
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Symbol: Rag2
Name: recombination activating gene 2
Description: Exhibits several functions, including methylated histone binding activity; phosphatidylinositol phosphate binding activity; and zinc ion binding activity. Involved in several processes, including B cell homeostatic proliferation; immune system development; and positive regulation of organ growth. Predicted to localize to DNA recombinase complex. Is expressed in gut; hemolymphoid system; and liver. Used to study Omenn syndrome and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in Omenn syndrome; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2); PARTICIPATES IN histone modification pathway; primary immunodeficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Rag-2; recombinase activating gene 2; recombination activating protein 2; V(D)J recombination-activating protein 2
Orthologs:
Homo sapiens (human) : RAG2 (recombination activating 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rag2 (recombination activating 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rag2 (recombination activating 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RAG2 (recombination activating 2)
Canis lupus familiaris (dog) : RAG2 (recombination activating 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rag2 (recombination activating 2)
Sus scrofa (pig) : RAG2 (recombination activating 2)
Chlorocebus sabaeus (African green monkey) : RAG2 (recombination activating 2)
Heterocephalus glaber (naked mole-rat) : Rag2 (recombination activating 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl2101,624,718 - 101,632,529 (+)EnsemblGRCm38mm10GRCm38
GRCm382101,624,712 - 101,632,528 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372101,464,905 - 101,472,685 (+)NCBIGRCm37mm9NCBIm37
MGSCv362101,425,587 - 101,433,367 (+)NCBImm8
Celera2102,849,742 - 102,857,519 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map253.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Rag2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313707
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.