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Gene: SMARCE1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1) Homo sapiens
Symbol: SMARCE1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Description: Exhibits N-acetyltransferase activity; nuclear receptor binding activity; and protein N-terminus binding activity. Contributes to RNA polymerase II distal enhancer sequence-specific DNA binding activity; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Involved in chromatin remodeling; negative regulation of transcription, DNA-templated; and nucleosome disassembly. Localizes to the SWI/SNF complex and nucleoplasm. Implicated in familial meningioma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BAF57; BRG1-associated factor 57; chromatin remodeling complex BRG1-associated factor 57; CSS5; FLJ35648; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Related Pseudogenes: SMARCE1P1   SMARCE1P2   SMARCE1P3   SMARCE1P4   SMARCE1P5   SMARCE1P6   SMARCE1P7  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381740,624,962 - 40,647,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371738,781,214 - 38,805,658 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,037,498 - 36,057,629 (-)NCBINCBI36hg18NCBI36
Build 341736,037,505 - 36,057,629NCBI
Celera1735,445,555 - 35,465,686 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1734,578,544 - 34,598,673 (-)NCBIHuRef
CHM1_11739,019,316 - 39,039,446 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SMARCE1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313743
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.