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Gene: TBK1 (TANK binding kinase 1) Homo sapiens
Symbol: TBK1
Name: TANK binding kinase 1
CRRD ID: 1313752
Description: Exhibits phosphoprotein binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of gene expression; and protein phosphorylation. Localizes to cytoplasm and nucleoplasm. Implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ11330; FTDALS4; IIAE8; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1
Mus musculus (house mouse) : Tbk1 (TANK-binding kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tbk1 (TANK-binding kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbk1 (TANK binding kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TBK1 (TANK binding kinase 1)
Canis lupus familiaris (dog) : TBK1 (TANK binding kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbk1 (TANK binding kinase 1)
Sus scrofa (pig) : TBK1 (TANK binding kinase 1)
Chlorocebus sabaeus (African green monkey) : TBK1 (TANK binding kinase 1)
Heterocephalus glaber (naked mole-rat) : Tbk1 (TANK binding kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1264,452,092 - 64,502,114 (+)EnsemblGRCh38hg38GRCh38
GRCh381264,452,105 - 64,502,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371264,845,840 - 64,895,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,132,204 - 63,182,158 (+)NCBINCBI36hg18NCBI36
Build 341263,132,203 - 63,182,158NCBI
Celera1264,510,375 - 64,560,181 (+)NCBI
Cytogenetic Map12q14.2NCBI
HuRef1261,898,186 - 61,948,226 (+)NCBIHuRef
CHM1_11264,812,935 - 64,863,007 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TBK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313752
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.