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Gene: Tbk1 (TANK-binding kinase 1) Mus musculus
Symbol: Tbk1
Name: TANK-binding kinase 1
CRRD ID: 1313753
Description: Exhibits several functions, including identical protein binding activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including dendritic cell proliferation; positive regulation of response to biotic stimulus; and regulation of gene expression. Predicted to localize to cytoplasm and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200008B05Rik; AI462036; AW048562; MGC150301; MGC150302; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K
Homo sapiens (human) : TBK1 (TANK binding kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tbk1 (TANK-binding kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbk1 (TANK binding kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TBK1 (TANK binding kinase 1)
Canis lupus familiaris (dog) : TBK1 (TANK binding kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbk1 (TANK binding kinase 1)
Sus scrofa (pig) : TBK1 (TANK binding kinase 1)
Chlorocebus sabaeus (African green monkey) : TBK1 (TANK binding kinase 1)
Heterocephalus glaber (naked mole-rat) : Tbk1 (TANK binding kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910121,382,360 - 121,422,699 (-)NCBI
GRCm3810121,546,455 - 121,586,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,546,455 - 121,586,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710120,983,511 - 121,023,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610120,949,520 - 120,989,807 (-)NCBImm8
Celera10123,931,313 - 123,970,044 (-)NCBICelera
Cytogenetic Map10D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tbk1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313753
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.