Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Tbk1 (TANK-binding kinase 1) Mus musculus
Analyze
Symbol: Tbk1
Name: TANK-binding kinase 1
Description: Exhibits several functions, including identical protein binding activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including dendritic cell proliferation; positive regulation of defense response; and positive regulation of interferon-beta biosynthetic process. Predicted to localize to the cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in FTDALS4 and brain disease. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TBK1 (TANK binding kinase 1); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200008B05Rik; AI462036; AW048562; MGC150301; MGC150302; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K
Orthologs:
Homo sapiens (human) : TBK1 (TANK binding kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tbk1 (TANK-binding kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbk1 (TANK binding kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TBK1 (TANK binding kinase 1)
Canis lupus familiaris (dog) : TBK1 (TANK binding kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbk1 (TANK binding kinase 1)
Sus scrofa (pig) : TBK1 (TANK binding kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3810121,546,455 - 121,586,794 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710120,983,511 - 121,023,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610120,949,520 - 120,989,807 (-)NCBImm8
Celera10123,931,313 - 123,970,044 (-)NCBICelera
Cytogenetic Map10 D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tbk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313753
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.