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Gene: Pikfyve (phosphoinositide kinase, FYVE type zinc finger containing) Mus musculus
Symbol: Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Description: Exhibits 1-phosphatidylinositol-4-phosphate 5-kinase activity and zinc ion binding activity. Involved in intracellular signal transduction and myelin assembly. Localizes to several cellular components, including cell-cell junction; perinuclear region of cytoplasm; and vesicle membrane. Is expressed in brain; genitourinary system; integumental system; limb; and skeleton. Used to study Crohn's disease. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing); PARTICIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; inositol phosphate metabolic pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 4-hydroxyphenyl retinamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; 5230400C17Rik; FYVE finger-containing phosphoinositide kinase; p235; phosphatidylinositol 3-phosphate 5-kinase; phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphatidylinositol-4-phosphate 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; Pip5k; Pip5k3; Pipk5k3; PipkIII; PIPkin-III; PtdIns(4)P-5-kinase; type III PIP kinase
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl165,186,683 - 65,278,695 (+)EnsemblGRCm38mm10GRCm38
GRCm38165,186,640 - 65,278,696 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37165,233,259 - 65,325,270 (+)NCBIGRCm37mm9NCBIm37
MGSCv36165,120,978 - 65,208,034 (+)NCBImm8
Celera165,677,339 - 65,769,254 (+)NCBICelera
Cytogenetic Map1C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Pikfyve
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313819
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.