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Gene: Otx2 (orthodenticle homeobox 2) Mus musculus
Symbol: Otx2
Name: orthodenticle homeobox 2
CRRD ID: 1313893
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to leukemia inhibitory factor; nervous system development; and regionalization. Localizes to cytoplasm; nucleus; and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Orthologous to human OTX2 (orthodenticle homeobox 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E130306E05Rik; homeobox protein OTX2; orthodenticle homolog 2
Homo sapiens (human) : OTX2 (orthodenticle homeobox 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Otx2 (orthodenticle homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Otx2 (orthodenticle homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : OTX2 (orthodenticle homeobox 2)
Canis lupus familiaris (dog) : OTX2 (orthodenticle homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Otx2 (orthodenticle homeobox 2)
Sus scrofa (pig) : OTX2 (orthodenticle homeobox 2)
Chlorocebus sabaeus (African green monkey) : OTX2 (orthodenticle homeobox 2)
Heterocephalus glaber (naked mole-rat) : Otx2 (orthodenticle homeobox 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391448,894,238 - 48,905,101 (-)NCBI
GRCm381448,656,781 - 48,667,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1448,657,677 - 48,673,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv371449,277,846 - 49,282,547 (-)NCBIGRCm37mm9NCBIm37
MGSCv361447,579,630 - 47,587,057 (-)NCBImm8
Celera1444,858,278 - 44,862,991 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1425.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Otx2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313893
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.