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Gene: LRP8 (LDL receptor related protein 8) Homo sapiens
Symbol: LRP8
Name: LDL receptor related protein 8
Description: Exhibits very-low-density lipoprotein particle receptor activity. Involved in endocytosis. Localizes to the caveola and receptor complex. Implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ApoE receptor 2; APOER2; apolipoprotein E receptor 2; HSZ75190; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; low-density lipoprotein receptor-related protein 8; LRP-8; MCI1; RP5-1024G6.8
Mus musculus (house mouse) : Lrp8 (low density lipoprotein receptor-related protein 8, apolipoprotein e receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrp8 (LDL receptor related protein 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp8 (LDL receptor related protein 8)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP8 (LDL receptor related protein 8)
Canis lupus familiaris (dog) : LRP8 (LDL receptor related protein 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp8 (LDL receptor related protein 8)
Sus scrofa (pig) : LRP8 (LDL receptor related protein 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38153,242,364 - 53,328,070 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37153,708,036 - 53,793,821 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36153,483,800 - 53,566,409 (-)NCBINCBI36hg18NCBI36
Celera151,999,058 - 52,081,130 (-)NCBI
Cytogenetic Map1p32.3NCBI
HuRef151,823,713 - 51,909,108 (-)NCBIHuRef
CHM1_1153,825,039 - 53,910,558 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LRP8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313932
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.