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Gene: TYMP (thymidine phosphorylase) Homo sapiens
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Symbol: TYMP
Name: thymidine phosphorylase
Description: Exhibits protein homodimerization activity and thymidine phosphorylase activity. Involved in several processes, including regulation of gastric motility; regulation of myelination; and regulation of transmission of nerve impulse. Predicted to localize to the cytosol. Implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Biomarker of several diseases, including carcinoma (multiple); common bile duct neoplasm; ductal carcinoma in situ; female reproductive organ cancer (multiple); and germ cell cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ECGF; ECGF1; gliostatin; hPD-ECGF; MEDPS1; MNGIE; MNGIE; MTDPS1; myoneurogastrointestinal encephalopathy syndrome; PDECGF; tdRPase; TP
Orthologs:
Mus musculus (house mouse) : Tymp (thymidine phosphorylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tymp (thymidine phosphorylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tymp (thymidine phosphorylase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYMP (thymidine phosphorylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tymp (thymidine phosphorylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,525,752 - 50,530,085 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372250,964,181 - 50,968,514 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,311,047 - 49,315,321 (-)NCBINCBI36hg18NCBI36
Build 342249,254,324 - 49,258,599NCBI
Celera2234,840,208 - 34,844,541 (-)NCBI
Cytogenetic Map22q13.33ENTREZGENE
HuRef2233,855,199 - 33,859,532 (-)NCBIHuRef
CHM1_12250,922,918 - 50,927,220 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TYMP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313979
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.