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Gene: PXN (paxillin) Homo sapiens
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Symbol: PXN
Name: paxillin
Description: Exhibits several functions, including beta-catenin binding activity; neuropilin binding activity; and vinculin binding activity. Involved in several processes, including endothelial cell migration; enzyme linked receptor protein signaling pathway; and positive regulation of stress fiber assembly. Localizes to several cellular components, including the focal adhesion; lamellipodium; and stress fiber.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ16691; testicular tissue protein Li 134
Orthologs:
Mus musculus (house mouse) : Pxn (paxillin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pxn (paxillin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pxn (paxillin)
Pan paniscus (bonobo/pygmy chimpanzee) : PXN (paxillin)
Canis lupus familiaris (dog) : PXN (paxillin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pxn (paxillin)
Sus scrofa (pig) : PXN (paxillin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,210,439 - 120,265,771 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712120,648,242 - 120,703,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,132,640 - 119,187,892 (-)NCBINCBI36hg18NCBI36
Build 3412119,110,976 - 119,166,229NCBI
Celera12120,281,352 - 120,336,672 (-)NCBI
Cytogenetic Map12q24.23NCBI
HuRef12117,656,442 - 117,711,723 (-)NCBIHuRef
CHM1_112120,616,253 - 120,671,571 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PXN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313984
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.