Gene: Kera (keratocan) Mus musculus
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Symbol:
Kera
Name:
keratocan
Description:
Involved in cornea development in camera-type eye. Predicted to localize to the extracellular region. Used to study cornea plana. Human ortholog(s) of this gene implicated in arcus senilis; cornea plana; and corneal dystrophy. Is expressed in several structures, including central nervous system; cranial muscle; jaw; limb mesenchyme; and sensory organ. Orthologous to human KERA (keratocan); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; dibutyl phthalate; tetracycline.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
CNA2; keratan sulfate proteoglycan keratocan; KTN; SLRR2B
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
KERA (keratocan) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Kera (keratocan) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Kera (keratocan) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
KERA (keratocan) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
KERA (keratocan) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Kera (keratocan) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
KERA (keratocan) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Kera (keratocan)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
KERA (keratocan)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
kera (keratocan)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
CG18095
Alliance
DIOPT (PANTHER, PhylomeDB)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 10 97,606,962 - 97,613,688 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 10 97,069,839 - 97,076,322 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 10 97,036,893 - 97,043,376 (+) NCBI mm8 Celera 10 99,578,265 - 99,584,748 (+) NCBI Celera Cytogenetic Map 10 C3 NCBI cM Map 10 50.34 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Cornea Plana 2 ISO RGD:1314078 8554872 ClinVar Annotator: match by OMIM:217300 ClinVar PMID:11726611 Cornea Plana 2 ISO RGD:1314078 8554872 ClinVar Annotator: match by OMIM:217300 ClinVar PMID:16234475 , PMID:23834557 Cornea Plana 2 ISO RGD:1314078 8554872 ClinVar Annotator: match by OMIM:217300 ClinVar PMID:23834557 Cornea Plana 2 ISO RGD:1314078 8554872 ClinVar Annotator: match by OMIM:217300 ClinVar PMID:10802664 , PMID:11754099 Cornea Plana 2 ISO RGD:1314078 8554872 ClinVar Annotator: match by OMIM:217300 ClinVar PMID:15370545 Cornea Plana 2 ISO RGD:1314078 8554872 ClinVar Annotator: match by OMIM:217300 ClinVar PMID:10802664 Cornea Plana 2 ISO RGD:1314078 8554872 ClinVar Annotator: match by OMIM:217300 ClinVar PMID:17011957 Cornea Plana 2 ISO RGD:1314078 8554872 ClinVar Annotator: match by OMIM:217300 ClinVar PMID:16157807
Imported Annotations - MGI
cornea plana IEA 13592920 OMIM:121400 , OMIM:217300MouseDO cornea plana ISS RGD:1314078 13592920 OMIM:121400 , OMIM:217300MouseDO Imported Annotations - OMIM
Cornea Plana 2 ISO RGD:1314078 7240710 OMIM
Gene-Chemical Interaction Annotations
1,2-dimethylhydrazine multiple interactions ISO RGD:1305816 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in decreased expression of KERA mRNA CTD PMID:27840820 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of KERA mRNA CTD PMID:21570461 acrylamide increases expression ISO RGD:1305816 6480464 Acrylamide results in increased expression of KERA mRNA CTD PMID:28959563 aflatoxin B1 decreases methylation ISO RGD:1314078 6480464 Aflatoxin B1 results in decreased methylation of KERA gene CTD PMID:27153756 antirheumatic drug increases expression ISO RGD:1314078 6480464 Antirheumatic Agents results in increased expression of KERA mRNA CTD PMID:24449571 bisphenol A decreases expression ISO RGD:1305816 6480464 bisphenol A results in decreased expression of KERA mRNA CTD PMID:25181051 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of KERA mRNA CTD PMID:21266533 manganese atom increases expression ISO RGD:1305816 6480464 Manganese results in increased expression of KERA mRNA CTD PMID:26745496 manganese(0) increases expression ISO RGD:1305816 6480464 Manganese results in increased expression of KERA mRNA CTD PMID:26745496 manganese(II) chloride increases expression ISO RGD:1305816 6480464 manganese chloride results in increased expression of KERA mRNA CTD PMID:26745496 tetracycline increases expression EXP 6480464 Tetracycline results in increased expression of KERA mRNA CTD PMID:16917069 trichloroethene decreases methylation ISO RGD:1305816 6480464 Trichloroethylene results in decreased methylation of KERA gene CTD PMID:27618143 valproic acid affects expression ISO RGD:1314078 6480464 Valproic Acid affects the expression of KERA mRNA CTD PMID:25979313 vorinostat increases expression ISO RGD:1314078 6480464 vorinostat results in increased expression of KERA mRNA CTD PMID:27188386
Gene Ontology Annotations
Phenotype Annotations
1301165 Lith7_m lithogenic gene 7 (mouse) Not determined 10 82473556 116473795 Mouse 11059553 Lmr32d_m leishmaniasis resistance 32d (mouse) 10 82473556 116473795 Mouse 1302060 El3_m epilepsy 3 (mouse) Not determined 10 65655104 99655287 Mouse 1300921 Skl4_m skeletal size (tail length) 4 (mouse) Not determined 10 88252393 122252530 Mouse 1301758 Fcsa3_m femoral cross-sectional area 3 (mouse) Not determined 10 90091790 124091893 Mouse 14747004 Mancz8_m mandible centroid size 8 (mouse) 10 82242550 116242550 Mouse 1301520 Uvbi1_m UVB induced immunosuppression 1 (mouse) Not determined 10 87073224 121073368 Mouse 13208554 Lgth11_m body length 11 (mouse) 10 91000000 121000000 Mouse 1357594 Estoq3_m embryo survival total QTL 3 (mouse) Not determined 10 84243786 122205623 Mouse 1300908 Insq4_m insulin QTL 4 (mouse) Not determined 10 87073224 121073368 Mouse 10043881 Adip24_m adiposity 24 (mouse) Not determined 10 82556941 116557090 Mouse 4141479 W10q8_m weight 10 weeks QTL 8 (mouse) Not determined 84243786 122205623 Mouse 4142074 Tmevp2_m Theiler's murine encephalomyelitis virus persistence 2 (mouse) Not determined 92894079 111732414 Mouse 1357638 Cia29_m collagen induced arthritis 29 (mouse) Not determined 10 85619118 118661448 Mouse 11039497 Ltpr5a_m Leishmania tropica response 5a (mouse) 10 73671039 107671185 Mouse 1558757 Eae34_m experimental allergic encephalomyelitis susceptibility 34 (mouse) Not determined 10 21532255 114381325 Mouse 11059551 Lmr32b_m leishmaniasis resistance 32b (mouse) 10 82473556 116473795 Mouse 1357632 Vtbt9_m vertebral trabecular bone trait 9 (mouse) Not determined 10 75502706 109502905 Mouse 4142137 Femwf3_m femur work to failure 3 (mouse) Not determined 75502706 109502905 Mouse 1300533 Aem3_m anti-erythrocyte autoantibody modifier 3 (mouse) Not determined 10 65655104 99655287 Mouse 11533921 Mvb2_m modifier of vibrator 2 (mouse) 10 97381196 130694993 Mouse 11251717 Siim1_m stress induced immobility 1 (mouse) 10 78545406 112545406 Mouse 1300975 Fembrs3_m femur breaking strength 3 (mouse) Not determined 10 75502706 109502905 Mouse 4142496 W6q8_m weight 6 weeks QTL 8 (mouse) Not determined 84243786 122205623 Mouse 12910821 Ogrq4_m overall growth rate QTL 4 (mouse) 10 92333194 107484128 Mouse 1357831 Igf1sl2_m IGF-1 serum levels 2 (mouse) Not determined 10 87858265 100100416 Mouse 11059554 Lmr32e_m leishmaniasis resistance 32e (mouse) 10 82473556 116473795 Mouse 13208560 Wght9_m weight 9 (mouse) 10 60000000 121000000 Mouse 4141054 mwfh_m modifier of white forlock hypopigmentation (mouse) Not determined 83181141 117181274 Mouse 1357779 Tesq3_m testis weight QTL 3 (mouse) Not determined 10 84243786 122205623 Mouse 11533919 Mvb4_m modifier of vibrator 4 (mouse) 3 97381196 130694993 Mouse 11353832 Pcholq4_m plasma cholesterol QTL 4 (mouse) 10 74151384 125680038 Mouse 4142461 Bmd25_m bone mineral density 25 (mouse) Not determined 10 97381196 130694993 Mouse 1300797 Sluc22_m susceptibility to lung cancer 22 (mouse) Not determined 10 86877747 120877895 Mouse 4142386 Tgq20_m triglyceride QTL 20 (mouse) Not determined 89000595 123000595 Mouse 11039516 Ltpr5_m Leishmania tropica response 5 (mouse) 10 90671039 125739363 Mouse 11353843 Gluq1_m blood glucose QTL 1 (mouse) 10 74151384 125680038 Mouse 4142365 Egq9_m early growth QTL 9 (mouse) Not determined 84243786 122205623 Mouse 1357622 Espq3_m embryo survival preimplantation QTL 3 (mouse) Not determined 10 84243786 122205623 Mouse 11059550 Lmr32a_m leishmaniasis resistance 32a (mouse) 10 82473556 116473795 Mouse 1357740 Obsty3_m obesity 3 (mouse) Not determined 10 8359714 116355075 Mouse 1302162 Ednrbm1_m endothelin receptor type B modifier 1 (mouse) Not determined 10 92291521 103877895 Mouse 4141387 Lgaq5_m late growth adjusted QTL 5 (mouse) Not determined 84243786 122205623 Mouse 1357544 Vtbt10_m vertebral trabecular bone trait 10 (mouse) Not determined 10 97381196 130694993 Mouse 1302067 Scc9_m colon tumor susceptibility 9 (mouse) Not determined 10 18383585 125739363 Mouse 11059555 Lmr32f_m leishmaniasis resistance 32f (mouse) 10 82473556 116473795 Mouse 1301737 Insq9_m insulin QTL 9 (mouse) Not determined 10 65655104 99655287 Mouse
Predicted Target Of
Count of predictions: 151 Count of miRNA genes: 133 Interacting mature miRNAs: 140 Transcripts: ENSMUST00000105286 Prediction methods: Miranda, Rnahybrid Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
