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Gene: ARPC2 (actin related protein 2/3 complex subunit 2) Homo sapiens
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Symbol: ARPC2
Name: actin related protein 2/3 complex subunit 2
Description: A structural constituent of cytoskeleton. Contributes to actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation and positive regulation of lamellipodium assembly. Localizes to Arp2/3 protein complex and lamellipodium. Biomarker of colorectal adenocarcinoma; invasive ductal carcinoma; melanoma; and systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: actin related protein 2/3 complex subunit 2, 34kDa; actin related protein 2/3 complex, subunit 2, 34kDa; actin-related protein 2/3 complex subunit 2; ARC34; arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34; p34-Arc; PNAS-139; PRO2446; testis tissue sperm-binding protein Li 53e
Orthologs:
Mus musculus (house mouse) : Arpc2 (actin related protein 2/3 complex, subunit 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arpc2 (actin related protein 2/3 complex, subunit 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arpc2 (actin related protein 2/3 complex subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ARPC2 (actin related protein 2/3 complex subunit 2)
Canis lupus familiaris (dog) : ARPC2 (actin related protein 2/3 complex subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arpc2 (actin related protein 2/3 complex subunit 2)
Sus scrofa (pig) : ARPC2 (actin related protein 2/3 complex subunit 2)
Chlorocebus sabaeus (African green monkey) : ARPC2 (actin related protein 2/3 complex subunit 2)
Heterocephalus glaber (naked mole-rat) : Arpc2 (actin related protein 2/3 complex subunit 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2218,217,141 - 218,254,356 (+)EnsemblGRCh38hg38GRCh38
GRCh382218,217,138 - 218,254,348 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,081,817 - 219,119,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,790,119 - 218,827,316 (+)NCBINCBI36hg18NCBI36
Build 342218,907,379 - 218,944,576NCBI
Celera2212,848,449 - 212,885,654 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2210,934,975 - 210,972,151 (+)NCBIHuRef
CHM1_12219,088,288 - 219,125,558 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on ARPC2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314126
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.