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Gene: KRIT1 (KRIT1 ankyrin repeat containing) Homo sapiens
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Symbol: KRIT1
Name: KRIT1 ankyrin repeat containing
Description: Exhibits microtubule binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cell redox homeostasis; negative regulation of endothelial cell apoptotic process; and negative regulation of endothelial cell migration. Localizes to the cell-cell junction and plasma membrane. Implicated in cerebral cavernous malformation and cerebral cavernous malformation 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ankyrin repeat-containing protein Krit1; CAM; CCM1; cerebral cavernous malformations 1; krev interaction trapped 1; krev interaction trapped protein 1; KRIT1, ankyrin repeat containing
Orthologs:
Mus musculus (house mouse) : Krit1 (KRIT1, ankyrin repeat containing)  MGI  Alliance
Rattus norvegicus (Norway rat) : Krit1 (KRIT1, ankyrin repeat containing)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Krit1 (KRIT1 ankyrin repeat containing)
Pan paniscus (bonobo/pygmy chimpanzee) : KRIT1 (KRIT1 ankyrin repeat containing)
Canis lupus familiaris (dog) : KRIT1 (KRIT1 ankyrin repeat containing)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Krit1 (KRIT1 ankyrin repeat containing)
Sus scrofa (pig) : KRIT1 (KRIT1 ankyrin repeat containing)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,198,969 - 92,246,100 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37791,828,283 - 91,875,414 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36791,666,219 - 91,713,350 (-)NCBINCBI36hg18NCBI36
Build 34791,472,933 - 91,520,065NCBI
Celera786,532,835 - 86,579,965 (-)NCBI
Cytogenetic Map7q21.2NCBI
HuRef786,435,945 - 86,483,492 (-)NCBIHuRef
CHM1_1791,758,320 - 91,805,450 (-)NCBICHM1_1
CRA_TCAGchr7v2791,157,516 - 91,204,647 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KRIT1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314251
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.