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Gene: KRIT1 (KRIT1 ankyrin repeat containing) Homo sapiens
Symbol: KRIT1
Name: KRIT1 ankyrin repeat containing
Description: Exhibits microtubule binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cell redox homeostasis; negative regulation of endothelial cell apoptotic process; and negative regulation of endothelial cell migration. Localizes to the cell-cell junction and plasma membrane. Implicated in cerebral cavernous malformation and cerebral cavernous malformation 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ankyrin repeat-containing protein Krit1; CAM; CCM1; cerebral cavernous malformations 1; krev interaction trapped 1; krev interaction trapped protein 1; KRIT1, ankyrin repeat containing
Mus musculus (house mouse) : Krit1 (KRIT1, ankyrin repeat containing)  MGI  Alliance
Rattus norvegicus (Norway rat) : Krit1 (KRIT1, ankyrin repeat containing)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Krit1 (KRIT1 ankyrin repeat containing)
Pan paniscus (bonobo/pygmy chimpanzee) : KRIT1 (KRIT1 ankyrin repeat containing)
Canis lupus familiaris (dog) : KRIT1 (KRIT1 ankyrin repeat containing)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Krit1 (KRIT1 ankyrin repeat containing)
Sus scrofa (pig) : KRIT1 (KRIT1 ankyrin repeat containing)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38792,198,969 - 92,246,100 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37791,828,283 - 91,875,414 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36791,666,219 - 91,713,350 (-)NCBINCBI36hg18NCBI36
Build 34791,472,933 - 91,520,065NCBI
Celera786,532,835 - 86,579,965 (-)NCBI
Cytogenetic Map7q21.2NCBI
HuRef786,435,945 - 86,483,492 (-)NCBIHuRef
CHM1_1791,758,320 - 91,805,450 (-)NCBICHM1_1
CRA_TCAGchr7v2791,157,516 - 91,204,647 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KRIT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314251
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.