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Gene: NCK2 (NCK adaptor protein 2) Homo sapiens
Symbol: NCK2
Name: NCK adaptor protein 2
Description: Exhibits phosphotyrosine residue binding activity. Involved in several processes, including negative regulation of protein phosphorylation; positive regulation of T cell proliferation; and positive regulation of actin filament polymerization. Localizes to the endoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cytoplasmic protein NCK2; GRB4; growth factor receptor-bound protein 4; NCKbeta; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK-beta
Mus musculus (house mouse) : Nck2 (non-catalytic region of tyrosine kinase adaptor protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nck2 (NCK adaptor protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nck2 (NCK adaptor protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NCK2 (NCK adaptor protein 2)
Canis lupus familiaris (dog) : NCK2 (NCK adaptor protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nck2 (NCK adaptor protein 2)
Sus scrofa (pig) : NCK2 (NCK adaptor protein 2)
Chlorocebus sabaeus (green monkey) : NCK2 (NCK adaptor protein 2)
Heterocephalus glaber (naked mole-rat) : Nck2 (NCK adaptor protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2105,744,912 - 105,894,274 (+)Ensembl
GRCh382105,744,649 - 105,894,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372106,361,520 - 106,510,730 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362105,727,786 - 105,877,160 (+)NCBINCBI36hg18NCBI36
Build 342105,819,871 - 105,969,244NCBI
Celera2100,633,297 - 100,711,182 (+)NCBI
Cytogenetic Map2q12.2NCBI
HuRef2100,201,822 - 100,279,928 (+)NCBIHuRef
CHM1_12106,365,834 - 106,515,058 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NCK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314306
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.