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Gene: NODAL (nodal growth differentiation factor) Homo sapiens
Symbol: NODAL
Name: nodal growth differentiation factor
Description: Exhibits type I activin receptor binding activity. Involved in several processes, including negative regulation of androgen receptor signaling pathway; positive regulation of cellular protein metabolic process; and positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to the extracellular space. Implicated in visceral heterotaxy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HTX5; MGC138230; nodal homolog
Mus musculus (house mouse) : Nodal (nodal)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nodal (nodal growth differentiation factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nodal (nodal growth differentiation factor)
Pan paniscus (bonobo/pygmy chimpanzee) : NODAL (nodal growth differentiation factor)
Canis lupus familiaris (dog) : NODAL (nodal growth differentiation factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nodal (nodal growth differentiation factor)
Sus scrofa (pig) : NODAL (nodal growth differentiation factor)
Chlorocebus sabaeus (African green monkey) : NODAL (nodal growth differentiation factor)
Heterocephalus glaber (naked mole-rat) : Nodal (nodal growth differentiation factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1070,431,936 - 70,447,951 (-)EnsemblGRCh38hg38GRCh38
GRCh381070,431,936 - 70,447,948 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371072,191,692 - 72,201,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,862,077 - 71,871,429 (-)NCBINCBI36hg18NCBI36
Build 341071,862,076 - 71,871,429NCBI
Celera1065,472,123 - 65,481,898 (-)NCBI
Cytogenetic Map10q22.1NCBI
HuRef1066,185,532 - 66,195,306 (-)NCBIHuRef
CHM1_11072,473,912 - 72,483,685 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NODAL
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314354
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.