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Gene: YAP1 (Yes1 associated transcriptional regulator) Homo sapiens
Symbol: YAP1
Name: Yes1 associated transcriptional regulator
CRRD ID: 1314421
Description: Exhibits DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of signal transduction; regulation of gene expression; and response to steroid hormone. Localizes to several cellular components, including TEAD-1-YAP complex; TEAD-2-YAP complex; and nucleus. Implicated in uveal coloboma-cleft lip and palate-intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 65 kDa Yes-associated protein; COB1; transcriptional coactivator YAP1; YAP; YAP2; YAP65; Yes associated protein 1; Yes-associated protein 1; Yes-associated protein 1, 65kDa; yes-associated protein 2; yes-associated protein beta; yes-associated protein delta; yes-associated protein YAP65 homolog; YKI; yorkie homolog
Mus musculus (house mouse) : Yap1 (yes-associated protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Yap1 (Yes1 associated transcriptional regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Yap1 (Yes1 associated transcriptional regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : YAP1 (Yes1 associated transcriptional regulator)
Canis lupus familiaris (dog) : YAP1 (Yes1 associated transcriptional regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Yap1 (Yes1 associated transcriptional regulator)
Sus scrofa (pig) : YAP1 (Yes1 associated transcriptional regulator)
Chlorocebus sabaeus (African green monkey) : YAP1 (Yes1 associated transcriptional regulator)
Heterocephalus glaber (naked mole-rat) : Yap1 (Yes1 associated transcriptional regulator)
more info ...
Related Pseudogenes: YAP1P1   YAP1P2   YAP1P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl11102,110,447 - 102,233,424 (+)EnsemblGRCh38hg38GRCh38
GRCh3811102,109,957 - 102,233,424 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711101,981,151 - 102,104,154 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,486,541 - 101,609,359 (+)NCBINCBI36hg18NCBI36
Build 3411101,486,540 - 101,609,356NCBI
Celera1199,142,746 - 99,265,700 (+)NCBI
Cytogenetic Map11q22.1NCBI
HuRef1197,907,865 - 98,030,476 (+)NCBIHuRef
CHM1_111101,864,181 - 101,987,123 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on YAP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314421
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-11-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.