Gene: Rom1 (rod outer segment membrane protein 1) Mus musculus
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Symbol:
Rom1
Name:
rod outer segment membrane protein 1
Description:
Involved in camera-type eye photoreceptor cell differentiation; regulation of gene expression; and retina vasculature development in camera-type eye. Localizes to the photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 7. Is expressed in photoreceptor layer; photoreceptor layer outer segment; and retina. Orthologous to human ROM1 (retinal outer segment membrane protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; paracetamol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
M101156; Rgsc1156; Rom-1; Rosp1; Tspan23
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ROM1 (retinal outer segment membrane protein 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Rom1 (retinal outer segment membrane protein 1) HGNC
Panther
Chinchilla lanigera (long-tailed chinchilla):
Rom1 (retinal outer segment membrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ROM1 (retinal outer segment membrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ROM1 (retinal outer segment membrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Rom1 (retinal outer segment membrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ROM1 (retinal outer segment membrane protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PRPH2 (peripherin 2) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Rom1 (retinal outer segment membrane protein 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
ROM1 (retinal outer segment membrane protein 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
rom1b (retinal outer segment membrane protein 1b)
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB, ZFIN)
Danio rerio (zebrafish):
rom1a (retinal outer segment membrane protein 1a)
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB, ZFIN)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 19 8,927,382 - 8,929,356 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 19 9,001,872 - 9,003,846 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 19 8,994,443 - 8,996,401 (-) NCBI mm8 Celera 19 8,688,158 - 8,690,132 (-) NCBI Celera Cytogenetic Map 19 A NCBI cM Map 19 6.03 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
macular degeneration ISO RGD:1314474 8554872 ClinVar Annotator: match by term: Macular dystrophy ClinVar PMID:30718709 retinitis pigmentosa ISO RGD:1314474 8554872 ClinVar Annotator: match by OMIM:268000 ClinVar retinitis pigmentosa ISO RGD:1314474 8554872 ClinVar Annotator: match by term: Retinitis Pigmentosa, Dominant ClinVar PMID:9331261 retinitis pigmentosa ISO RGD:1314474 8554872 ClinVar Annotator: match by term: Retinitis Pigmentosa, Dominant ClinVar PMID:20335603 , PMID:7904211 retinitis pigmentosa ISO RGD:1314474 8554872 ClinVar Annotator: match by term: Retinitis pigmentosa ClinVar PMID:8202715 retinitis pigmentosa ISO RGD:1314474 8554872 ClinVar Annotator: match by term: Retinitis pigmentosa ClinVar PMID:25741868 retinitis pigmentosa 7 ISO RGD:1314474 8554872 ClinVar Annotator: match by term: Retinitis pigmentosa 7, digenic ClinVar PMID:8202715
Imported Annotations - CTD
retinitis pigmentosa ISO RGD:1314474 11554173 CTD Direct Evidence: marker/mechanism CTD Imported Annotations - OMIM
retinitis pigmentosa 7 ISO RGD:1314474 7240710 OMIM
17beta-estradiol increases expression ISO RGD:1314474 6480464 Estradiol results in increased expression of ROM1 mRNA CTD PMID:17962382 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ROM1 mRNA CTD PMID:21570461 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1314474 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROM1 mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of ROM1 mRNA CTD PMID:18648102 acrylamide increases expression ISO RGD:1306070 6480464 Acrylamide results in increased expression of ROM1 mRNA CTD PMID:28959563 atrazine increases expression ISO RGD:1314474 6480464 Atrazine results in increased expression of ROM1 mRNA CTD PMID:22378314 bicalutamide increases expression ISO RGD:1314474 6480464 bicalutamide results in increased expression of ROM1 mRNA CTD PMID:15790403 bisphenol A decreases expression ISO RGD:1306070 6480464 bisphenol A results in decreased expression of ROM1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1314474 6480464 bisphenol A results in increased expression of ROM1 mRNA CTD PMID:27685785 bisphenol F multiple interactions ISO RGD:1314474 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROM1 mRNA CTD PMID:28628672 calcitriol increases expression ISO RGD:1314474 6480464 Calcitriol results in increased expression of ROM1 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1314474 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ROM1 mRNA CTD PMID:21592394 cisplatin increases expression ISO RGD:1314474 6480464 Cisplatin results in increased expression of ROM1 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1314474 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of ROM1 mRNA CTD PMID:27392435 dexamethasone multiple interactions ISO RGD:1314474 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROM1 mRNA CTD PMID:28628672 dorsomorphin multiple interactions ISO RGD:1314474 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROM1 mRNA CTD PMID:27188386 indometacin multiple interactions ISO RGD:1314474 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROM1 mRNA CTD PMID:28628672 menadione affects expression ISO RGD:1314474 6480464 Vitamin K 3 affects the expression of ROM1 mRNA CTD PMID:20044591 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of ROM1 mRNA CTD PMID:17562736 perfluorooctanoic acid increases expression ISO RGD:1306070 6480464 perfluorooctanoic acid results in increased expression of ROM1 mRNA CTD PMID:19162173 phenobarbital affects expression ISO RGD:1314474 6480464 Phenobarbital affects the expression of ROM1 mRNA CTD PMID:19159669 pirinixic acid increases expression ISO RGD:1306070 6480464 pirinixic acid results in increased expression of ROM1 mRNA CTD PMID:19162173 raloxifene increases expression ISO RGD:1314474 6480464 Raloxifene Hydrochloride results in increased expression of ROM1 mRNA CTD PMID:17962382 SB 431542 multiple interactions ISO RGD:1314474 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROM1 mRNA CTD PMID:27188386 testosterone multiple interactions ISO RGD:1314474 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ROM1 mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:1314474 6480464 Testosterone results in increased expression of ROM1 mRNA CTD PMID:21592394 valproic acid decreases expression ISO RGD:1314474 6480464 Valproic Acid results in decreased expression of ROM1 mRNA CTD PMID:26272509 valproic acid multiple interactions ISO RGD:1314474 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROM1 mRNA CTD PMID:27188386
Biological Process camera-type eye photoreceptor cell differentiation IMP 2290270 (MGI:MGI:4437581, PMID:20300562) MGI MGI:MGI:4437581 , PMID:20300562 cell adhesion IEA UniProtKB-KW:KW-0130 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 regulation of gene expression IMP 2290270 (MGI:MGI:4437581, PMID:20300562) MGI MGI:MGI:4437581 , PMID:20300562 retina morphogenesis in camera-type eye IMP 2290270 (MGI:MGI:4437581, PMID:20300562) MGI MGI:MGI:4437581 , PMID:20300562 retina vasculature development in camera-type eye IMP 2290270 (MGI:MGI:4437581, PMID:20300562) MGI MGI:MGI:4437581 , PMID:20300562 visual perception IEA InterPro:IPR000830 , InterPro:IPR018498 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 Cellular Component integral component of membrane IEA InterPro:IPR000830 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 integral component of plasma membrane IBA MGI:MGI:1889818 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 photoreceptor outer segment IDA 2290270 (MGI:MGI:4461813 more ... MGI MGI:MGI:4461813 more ... photoreceptor outer segment membrane IDA 2290270 (MGI:MGI:3814988, PMID:18654668) BHF-UCL MGI:MGI:3814988 , PMID:18654668 Molecular Function molecular_function ND 2290270 MGI GO_REF:0000015, MGI:MGI:2156816
Gene-Chemical Interaction Annotations
