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Gene: Gli3 (GLI-Kruppel family member GLI3) Mus musculus
Symbol: Gli3
Name: GLI-Kruppel family member GLI3
CRRD ID: 1314554
Description: Exhibits DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cell differentiation. Localizes to axoneme; nuclear speck; and transcription repressor complex. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; limb; and sensory organ. Used to study Greig cephalopolysyndactyly syndrome and Pallister-Hall syndrome. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: add; AI854843; anterior digit pattern deformity; AU023367; Bp; Bph; brachyphalangy; extra toes; GLI3 form of 190 kDa; GLI3 full length protein; GLI3-190; GLI3FL; Pdn; polydactyly Nagoya; transcriptional activator GLI3; Xt; zinc finger protein GLI3
Homo sapiens (human) : GLI3 (GLI family zinc finger 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gli3 (GLI family zinc finger 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gli3 (GLI family zinc finger 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GLI3 (GLI family zinc finger 3)
Canis lupus familiaris (dog) : GLI3 (GLI family zinc finger 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gli3 (GLI family zinc finger 3)
Sus scrofa (pig) : GLI3 (GLI family zinc finger 3)
Chlorocebus sabaeus (African green monkey) : GLI3 (GLI family zinc finger 3)
Heterocephalus glaber (naked mole-rat) : Gli3 (GLI family zinc finger 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391315,638,308 - 15,904,611 (+)NCBI
GRCm381315,463,723 - 15,730,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1315,463,235 - 15,730,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv371315,555,556 - 15,821,859 (+)NCBIGRCm37mm9NCBIm37
MGSCv361315,254,867 - 15,517,860 (+)NCBImm8
Celera1315,745,941 - 16,017,370 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gli3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314554
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.