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Gene: Gli3 (GLI-Kruppel family member GLI3) Mus musculus
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Symbol: Gli3
Name: GLI-Kruppel family member GLI3
CRRD ID: 1314554
Description: Exhibits DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cell differentiation. Localizes to axoneme; nuclear speck; and transcription repressor complex. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; limb; and sensory organ. Used to study Greig cephalopolysyndactyly syndrome and Pallister-Hall syndrome. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: add; AI854843; anterior digit pattern deformity; AU023367; Bp; Bph; brachyphalangy; extra toes; GLI3 form of 190 kDa; GLI3 full length protein; GLI3-190; GLI3FL; Pdn; polydactyly Nagoya; transcriptional activator GLI3; Xt; zinc finger protein GLI3
Orthologs:
Homo sapiens (human) : GLI3 (GLI family zinc finger 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gli3 (GLI family zinc finger 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gli3 (GLI family zinc finger 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GLI3 (GLI family zinc finger 3)
Canis lupus familiaris (dog) : GLI3 (GLI family zinc finger 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gli3 (GLI family zinc finger 3)
Sus scrofa (pig) : GLI3 (GLI family zinc finger 3)
Chlorocebus sabaeus (African green monkey) : GLI3 (GLI family zinc finger 3)
Heterocephalus glaber (naked mole-rat) : Gli3 (GLI family zinc finger 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391315,638,308 - 15,904,611 (+)NCBI
GRCm381315,463,723 - 15,730,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1315,463,235 - 15,730,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv371315,555,556 - 15,821,859 (+)NCBIGRCm37mm9NCBIm37
MGSCv361315,254,867 - 15,517,860 (+)NCBImm8
Celera1315,745,941 - 16,017,370 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gli3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314554
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.