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Gene: PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha) Homo sapiens
Symbol: PIP5K1A
Name: phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Description: Exhibits 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Localizes to several cellular components, including the lamellipodium; nuclear speck; and ruffle membrane. Colocalizes with the mRNA cleavage and polyadenylation specificity factor complex; PARTICIPATES IN Arf family mediated signaling pathway; E-cadherin signaling pathway; phosphoinositide metabolic pathway; INTERACTS WITH 17beta-estradiol; 2-hydroxypropanoic acid; 5-azacytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; phosphatidylinositol 4-phosphate 5-kinase type I alpha; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PIP5K1-alpha; PIP5KIalpha; ptdIns(4)P-5-kinase 1 alpha
Related Pseudogenes: PIP5K1P1   PIP5K1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381151,197,954 - 151,249,536 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371151,171,021 - 151,222,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,437,696 - 149,488,629 (+)NCBINCBI36hg18NCBI36
Build 341147,984,144 - 148,035,078NCBI
Celera1124,286,312 - 124,337,297 (+)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1122,549,129 - 122,599,938 (+)NCBIHuRef
CHM1_11152,566,349 - 152,617,334 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PIP5K1A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314561
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.