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Gene: OVOL2 (ovo like zinc finger 2) Homo sapiens
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Symbol: OVOL2
Name: ovo like zinc finger 2
Description: Exhibits transcription regulatory region DNA binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of keratinocyte differentiation; and negative regulation of transcription by competitive promoter binding activity. Predicted to localize to the nucleus. Implicated in posterior polymorphous corneal dystrophy 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CHED; CHED1; CHED2; corneal endothelial dystrophy 1 (autosomal dominant); EUROIMAGE566589; hOvo2; ovo-like 2; ovo-like zinc finger 2; PPCD1; transcription factor Ovo-like 2; zinc finger protein 339; ZNF339
Orthologs:
Mus musculus (house mouse) : Ovol2 (ovo like zinc finger 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ovol2 (ovo-like zinc finger 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ovol2 (ovo like zinc finger 2)
Pan paniscus (bonobo/pygmy chimpanzee) : OVOL2 (ovo like zinc finger 2)
Canis lupus familiaris (dog) : OVOL2 (ovo like zinc finger 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ovol2 (ovo like zinc finger 2)
Sus scrofa (pig) : OVOL2 (ovo like zinc finger 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382018,024,152 - 18,059,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372018,004,796 - 18,039,834 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362017,952,796 - 17,986,521 (-)NCBINCBI36hg18NCBI36
Build 342017,952,795 - 17,986,521NCBI
Celera2018,079,347 - 18,113,079 (-)NCBI
Cytogenetic Map20p11.23NCBI
HuRef2017,967,242 - 18,001,367 (-)NCBIHuRef
CHM1_12018,004,853 - 18,039,861 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on OVOL2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314567
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.