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Gene: OVOL2 (ovo like zinc finger 2) Homo sapiens
Symbol: OVOL2
Name: ovo like zinc finger 2
CRRD ID: 1314567
Description: Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of keratinocyte differentiation; and negative regulation of transcription by competitive promoter binding activity. Predicted to localize to nucleus. Implicated in posterior polymorphous corneal dystrophy 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CHED; CHED1; CHED2; corneal endothelial dystrophy 1 (autosomal dominant); EUROIMAGE566589; hOvo2; ovo-like 2; ovo-like zinc finger 2; PPCD1; transcription factor Ovo-like 2; zinc finger protein 339; ZNF339
Mus musculus (house mouse) : Ovol2 (ovo like zinc finger 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ovol2 (ovo-like zinc finger 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ovol2 (ovo like zinc finger 2)
Pan paniscus (bonobo/pygmy chimpanzee) : OVOL2 (ovo like zinc finger 2)
Canis lupus familiaris (dog) : OVOL2 (ovo like zinc finger 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ovol2 (ovo like zinc finger 2)
Sus scrofa (pig) : OVOL2 (ovo like zinc finger 2)
Chlorocebus sabaeus (African green monkey) : OVOL2 (ovo like zinc finger 2)
Heterocephalus glaber (naked mole-rat) : Ovol2 (ovo like zinc finger 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2017,956,979 - 18,059,188 (-)EnsemblGRCh38hg38GRCh38
GRCh382018,024,152 - 18,059,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372018,004,796 - 18,039,834 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362017,952,796 - 17,986,521 (-)NCBINCBI36hg18NCBI36
Build 342017,952,795 - 17,986,521NCBI
Celera2018,079,347 - 18,113,079 (-)NCBI
Cytogenetic Map20p11.23NCBI
HuRef2017,967,242 - 18,001,367 (-)NCBIHuRef
CHM1_12018,004,853 - 18,039,861 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on OVOL2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314567
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.