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Gene: STUB1 (STIP1 homology and U-box containing protein 1) Homo sapiens
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Symbol: STUB1
Name: STIP1 homology and U-box containing protein 1
Description: This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen NY-CO-7; carboxy terminus of Hsp70-interacting protein; CHIP; CLL-associated antigen KW-8; E3 ubiquitin-protein ligase CHIP; heat shock protein A binding protein 2 (c-terminal); HSPABP2; NY-CO-7; RING-type E3 ubiquitin transferase CHIP; SCA48; SCAR16; SDCCAG7; serologically defined colon cancer antigen 7; STIP1 homology and U box-containing protein 1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; UBOX1
Orthologs:
Mus musculus (house mouse) : Stub1 (STIP1 homology and U-Box containing protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Stub1 (STIP1 homology and U-box containing protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Stub1 (STIP1 homology and U-box containing protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : STUB1 (STIP1 homology and U-box containing protein 1)
Canis lupus familiaris (dog) : STUB1 (STIP1 homology and U-box containing protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Stub1 (STIP1 homology and U-box containing protein 1)
Sus scrofa (pig) : STUB1 (STIP1 homology and U-box containing protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816680,410 - 682,801 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716730,115 - 732,768 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616670,116 - 672,769 (+)NCBINCBI36hg18NCBI36
Build 3416670,115 - 672,768NCBI
Celera16930,272 - 932,925 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef16651,974 - 654,645 (+)NCBIHuRef
CHM1_116730,085 - 732,742 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on STUB1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314629
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.