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Gene: PARL (presenilin associated rhomboid like) Homo sapiens
Symbol: PARL
Name: presenilin associated rhomboid like
Description: Exhibits endopeptidase activity. Involved in several processes, including membrane protein proteolysis; regulation of protein targeting to mitochondrion; and regulation of reactive oxygen species metabolic process. Localizes to the mitochondrion. Implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Biomarker of breast carcinoma and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: mitochondrial intramembrane cleaving protease PARL; mitochondrial intramembrane-cleaving protease PARL; presenilin associated, rhomboid-like; presenilins-associated rhomboid-like protein, mitochondrial; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1; rhomboid 7 homolog 1
Mus musculus (house mouse) : Parl (presenilin associated, rhomboid-like)  MGI  Alliance
Rattus norvegicus (Norway rat) : Parl (presenilin associated, rhomboid-like)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Parl (presenilin associated rhomboid like)
Pan paniscus (bonobo/pygmy chimpanzee) : PARL (presenilin associated rhomboid like)
Canis lupus familiaris (dog) : PARL (presenilin associated rhomboid like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Parl (presenilin associated rhomboid like)
Sus scrofa (pig) : PARL (presenilin associated rhomboid like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383183,826,488 - 183,884,901 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373183,543,522 - 183,602,693 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,029,867 - 185,085,387 (-)NCBINCBI36hg18NCBI36
Build 343185,029,881 - 185,085,356NCBI
Celera3181,990,550 - 182,046,014 (-)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3180,956,508 - 181,012,355 (-)NCBIHuRef
CHM1_13183,511,499 - 183,567,011 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PARL
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314669
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.