Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PARL (presenilin associated rhomboid like) Homo sapiens
Analyze
Symbol: PARL
Name: presenilin associated rhomboid like
Description: Exhibits endopeptidase activity. Involved in several processes, including membrane protein proteolysis; regulation of protein targeting to mitochondrion; and regulation of reactive oxygen species metabolic process. Localizes to the mitochondrion. Implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Biomarker of breast carcinoma and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: mitochondrial intramembrane cleaving protease PARL; mitochondrial intramembrane-cleaving protease PARL; presenilin associated, rhomboid-like; presenilins-associated rhomboid-like protein, mitochondrial; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1; rhomboid 7 homolog 1
Orthologs:
Mus musculus (house mouse) : Parl (presenilin associated, rhomboid-like)  MGI  Alliance
Rattus norvegicus (Norway rat) : Parl (presenilin associated, rhomboid-like)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Parl (presenilin associated rhomboid like)
Pan paniscus (bonobo/pygmy chimpanzee) : PARL (presenilin associated rhomboid like)
Canis lupus familiaris (dog) : PARL (presenilin associated rhomboid like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Parl (presenilin associated rhomboid like)
Sus scrofa (pig) : PARL (presenilin associated rhomboid like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383183,826,488 - 183,884,901 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373183,543,522 - 183,602,693 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,029,867 - 185,085,387 (-)NCBINCBI36hg18NCBI36
Build 343185,029,881 - 185,085,356NCBI
Celera3181,990,550 - 182,046,014 (-)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3180,956,508 - 181,012,355 (-)NCBIHuRef
CHM1_13183,511,499 - 183,567,011 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PARL
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314669
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.