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Gene: REXO4 (REX4 homolog, 3'-5' exonuclease) Homo sapiens
Symbol: REXO4
Name: REX4 homolog, 3'-5' exonuclease
Description: Exhibits nuclease activity; single-stranded DNA binding activity; and transcription coactivator activity. Involved in DNA metabolic process and positive regulation of transcription by RNA polymerase II. Localizes to the nuclear speck and nucleolus; INTERACTS WITH butan-1-ol; cadmium dichloride; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: exonuclease XPMC2; hPMC2; prevents mitotic catastrophe 2 protein homolog; REX4; REX4, RNA exonuclease 4 homolog; RNA exonuclease 4; Xenopus prevents mitotic catastrophe 2 homolog; Xenopus prevents mitotic catatrophe 2 homolog; XPMC2; XPMC2 prevents mitotic catastrophe 2 homolog; XPMC2H
Mus musculus (house mouse) : Rexo4 (REX4, 3'-5' exonuclease)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rexo4 (REX4 homolog, 3'-5' exonuclease)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rexo4 (REX4 homolog, 3'-5' exonuclease)
Pan paniscus (bonobo/pygmy chimpanzee) : REXO4 (REX4 homolog, 3'-5' exonuclease)
Canis lupus familiaris (dog) : REXO4 (REX4 homolog, 3'-5' exonuclease)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rexo4 (REX4 homolog, 3'-5' exonuclease)
Sus scrofa (pig) : REXO4 (REX4 homolog, 3'-5' exonuclease)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389133,406,058 - 133,418,172 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379136,271,182 - 136,283,292 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,261,007 - 135,272,985 (-)NCBINCBI36hg18NCBI36
Build 349133,300,741 - 133,312,718NCBI
Celera9106,821,755 - 106,833,737 (-)NCBI
Cytogenetic Map9q34.2NCBI
HuRef9105,773,009 - 105,785,123 (-)NCBIHuRef
CHM1_19136,421,689 - 136,433,799 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on REXO4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314713
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.