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Gene: Aloxe3 (arachidonate lipoxygenase 3) Mus musculus
Symbol: Aloxe3
Name: arachidonate lipoxygenase 3
CRRD ID: 1314766
Description: Exhibits hepoxilin A3 synthase activity. Involved in several processes, including establishment of skin barrier; long-chain fatty acid metabolic process; and peroxisome proliferator activated receptor signaling pathway. Predicted to localize to cytoplasm. Is expressed in epidermis. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOXE3 (arachidonate lipoxygenase 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: e-LOX; e-LOX-3; eLOX-3; epidermal LOX-3; epidermis-type lipoxygenase 3; hydroperoxide isomerase ALOXE3; hydroperoxy dehydratase ALOXE3; hydroperoxy icosatetraenoate dehydratase; hydroperoxy icosatetraenoate isomerase; MGC143829; MGC143830
Homo sapiens (human) : ALOXE3 (arachidonate lipoxygenase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aloxe3 (arachidonate lipoxygenase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aloxe3 (arachidonate lipoxygenase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOXE3 (arachidonate lipoxygenase 3)
Canis lupus familiaris (dog) : ALOXE3 (arachidonate lipoxygenase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aloxe3 (arachidonate lipoxygenase 3)
Sus scrofa (pig) : ALOXE3 (arachidonate lipoxygenase 3)
Chlorocebus sabaeus (African green monkey) : ALOXE3 (arachidonate lipoxygenase 3)
Heterocephalus glaber (naked mole-rat) : Aloxe3 (arachidonate lipoxygenase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1169,125,896 - 69,149,115 (+)EnsemblGRCm38mm10GRCm38
GRCm381169,125,417 - 69,149,115 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371168,939,879 - 68,962,617 (+)NCBIGRCm37mm9NCBIm37
MGSCv361168,942,572 - 68,965,309 (+)NCBImm8
Celera1176,069,912 - 76,093,792 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Aloxe3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314766
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.