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Gene: AP2A1 (adaptor related protein complex 2 subunit alpha 1) Homo sapiens
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Symbol: AP2A1
Name: adaptor related protein complex 2 subunit alpha 1
Description: Exhibits low-density lipoprotein particle receptor binding activity. Involved in clathrin-dependent endocytosis and negative regulation of hyaluronan biosynthetic process. Localizes to AP-2 adaptor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 100 kDa coated vesicle protein A; adapter-related protein complex 2 alpha-1 subunit; adapter-related protein complex 2 subunit alpha-1; adaptin, alpha A; adaptor protein complex AP-2 subunit alpha-1; adaptor related protein complex 2 alpha 1 subunit; adaptor related protein complex 2, alpha 1 subunit; adaptor-related protein complex 2 subunit alpha-1; adaptor-related protein complex 2, alpha 1 subunit; ADTAA; alpha-adaptin A; alpha1-adaptin; AP-2 complex subunit alpha-1; AP2-ALPHA; CLAPA1; clathrin assembly protein complex 2 alpha-A large chain; clathrin-associated/assembly/adaptor protein, large, alpha 1; plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
Orthologs:
Mus musculus (house mouse) : Ap2a1 (adaptor-related protein complex 2, alpha 1 subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ap2a1 (adaptor related protein complex 2 subunit alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ap2a1 (adaptor related protein complex 2 subunit alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AP2A1 (adaptor related protein complex 2 subunit alpha 1)
Canis lupus familiaris (dog) : AP2A1 (adaptor related protein complex 2 subunit alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ap2a1 (adaptor related protein complex 2 subunit alpha 1)
Sus scrofa (pig) : AP2A1 (adaptor related protein complex 2 subunit alpha 1)
Chlorocebus sabaeus (African green monkey) : AP2A1 (adaptor related protein complex 2 subunit alpha 1)
Heterocephalus glaber (naked mole-rat) : Ap2a1 (adaptor related protein complex 2 subunit alpha 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1949,766,968 - 49,807,113 (+)EnsemblGRCh38hg38GRCh38
GRCh381949,767,001 - 49,807,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,270,180 - 50,310,369 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,961,992 - 55,002,181 (+)NCBINCBI36hg18NCBI36
Build 341954,961,991 - 55,002,181NCBI
Celera1947,139,637 - 47,179,822 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1946,646,519 - 46,686,682 (+)NCBIHuRef
CHM1_11950,271,982 - 50,312,188 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AP2A1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314769
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.