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Gene: Tjp1 (tight junction protein 1) Mus musculus
Symbol: Tjp1
Name: tight junction protein 1
Description: Exhibits connexin binding activity and protein domain specific binding activity. Involved in several processes, including negative regulation of stress fiber assembly; positive regulation of sprouting angiogenesis; and sensory perception of sound. Localizes to several cellular components, including apicolateral plasma membrane; bicellular tight junction; and intercellular canaliculus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TJP1 (tight junction protein 1); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 1,2-dichloroethane; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gm1693; predicted gene 1693; tight junction protein ZO-1; ZO1; zona occludens protein 1; zonula occludens protein 1
Homo sapiens (human) : TJP1 (tight junction protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tjp1 (tight junction protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tjp1 (tight junction protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TJP1 (tight junction protein 1)
Canis lupus familiaris (dog) : TJP1 (tight junction protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tjp1 (tight junction protein 1)
Sus scrofa (pig) : TJP1 (tight junction protein 1)
Chlorocebus sabaeus (African green monkey) : TJP1 (tight junction protein 1)
Heterocephalus glaber (naked mole-rat) : Tjp1 (tight junction protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl765,296,165 - 65,527,781 (-)EnsemblGRCm38mm10GRCm38
GRCm38765,296,165 - 65,527,850 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37772,441,051 - 72,516,130 (-)NCBIGRCm37mm9NCBIm37
MGSCv36765,175,118 - 65,250,189 (-)NCBImm8
Celera762,713,602 - 62,789,529 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map735.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Tjp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314850
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.