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Gene: Ube3a (ubiquitin protein ligase E3A) Mus musculus
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Symbol: Ube3a
Name: ubiquitin protein ligase E3A
Description: Exhibits transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including cellular protein metabolic process; positive regulation of Golgi lumen acidification; and reproductive structure development. Localizes to cytosol and nucleus. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Is expressed in central nervous system and retina. Orthologous to human UBE3A (ubiquitin protein ligase E3A); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4732496B02; 5830462N02Rik; A130086L21Rik; E6-AP ubiquitin protein ligase; HECT-type ubiquitin transferase E3A; Hpve6a; KIAA4216; mKIAA4216; oncogenic protein-associated protein E6-AP; ubiquitin conjugating enzyme E3A; ubiquitin-protein ligase E3A
Orthologs:
Homo sapiens (human) : UBE3A (ubiquitin protein ligase E3A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ube3a (ubiquitin protein ligase E3A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ube3a (ubiquitin protein ligase E3A)
Pan paniscus (bonobo/pygmy chimpanzee) : UBE3A (ubiquitin protein ligase E3A)
Canis lupus familiaris (dog) : UBE3A (ubiquitin protein ligase E3A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ube3a (ubiquitin protein ligase E3A)
Sus scrofa (pig) : UBE3A (ubiquitin protein ligase E3A)
Chlorocebus sabaeus (African green monkey) : UBE3A (ubiquitin protein ligase E3A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl759,228,750 - 59,311,536 (+)EnsemblGRCm38mm10GRCm38
GRCm38759,228,750 - 59,310,837 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37766,484,120 - 66,562,097 (+)NCBIGRCm37mm9NCBIm37
MGSCv36748,955,227 - 49,033,145 (+)NCBImm8
MGSCv36759,096,619 - 59,174,596 (+)NCBImm8
Cytogenetic Map7B5NCBI
cM Map733.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ube3a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314935
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.