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Gene: NOD2 (nucleotide binding oligomerization domain containing 2) Homo sapiens
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Symbol: NOD2
Name: nucleotide binding oligomerization domain containing 2
CRRD ID: 1314945
Description: Exhibits several functions, including CARD domain binding activity; heat shock protein binding activity; and muramyl dipeptide binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule metabolic process; and response to bacterium. Localizes to several cellular components, including anchored component of plasma membrane; basolateral plasma membrane; and phagocytic vesicle. Implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Biomarker of allergic rhinitis and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACUG; BLAU; BLAUS; CARD15; caspase recruitment domain family, member 15; caspase recruitment domain protein 15; caspase recruitment domain-containing protein 15; CD; CLR16.3; IBD1; inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; NLRC2; NOD-like receptor C2; NOD2B; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain containing 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; nucleotide-binding oligomerization domain-containing protein 2; PSORAS1; YAOS
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1650,693,588 - 50,734,041 (+)EnsemblGRCh38hg38GRCh38
GRCh381650,693,587 - 50,733,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,727,507 - 50,766,990 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,288,551 - 49,324,488 (+)NCBINCBI36hg18NCBI36
Build 341649,288,550 - 49,324,488NCBI
Celera1635,246,377 - 35,282,313 (+)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1636,618,016 - 36,653,950 (+)NCBIHuRef
CHM1_11652,138,579 - 52,174,514 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants