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Gene: KDM4A (lysine demethylase 4A) Homo sapiens
Symbol: KDM4A
Name: lysine demethylase 4A
Description: Exhibits several functions, including histone demethylase activity; ubiquitin protein ligase binding activity; and zinc ion binding activity. Involved in histone lysine demethylation and negative regulation of cellular metabolic process. Localizes to nucleus. Biomarker of several diseases, including alopecia areata; lung cancer; prostate cancer; stomach carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; JHDM3A; jmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; jumonji domain-containing protein 2A; KIAA0677; lysine (K)-specific demethylase 4A; lysine-specific demethylase 4A; TDRD14A; tudor domain containing 14A
Mus musculus (house mouse) : Kdm4a (lysine (K)-specific demethylase 4A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm4a (lysine demethylase 4A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm4a (lysine demethylase 4A)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM4A (lysine demethylase 4A)
Canis lupus familiaris (dog) : KDM4A (lysine demethylase 4A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm4a (lysine demethylase 4A)
Sus scrofa (pig) : KDM4A (lysine demethylase 4A)
Chlorocebus sabaeus (African green monkey) : KDM4A (lysine demethylase 4A)
Heterocephalus glaber (naked mole-rat) : Kdm4a (lysine demethylase 4A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl143,650,149 - 43,705,518 (+)EnsemblGRCh38hg38GRCh38
GRCh38143,650,149 - 43,705,518 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37144,115,797 - 44,171,189 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,888,384 - 43,943,776 (+)NCBINCBI36hg18NCBI36
Build 34143,784,930 - 43,840,231NCBI
Celera142,397,631 - 42,453,018 (+)NCBI
Cytogenetic Map1p34.2-p34.1NCBI
HuRef142,236,372 - 42,291,619 (+)NCBIHuRef
CHM1_1144,232,091 - 44,287,481 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KDM4A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1314960
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.