Gene: EPN3 (epsin 3) Homo sapiens
Analyze
Symbol:
EPN3
Name:
epsin 3
Description:
Predicted to have EH domain binding activity and lipid binding activity. Localizes to several cellular components, including the clathrin-coated vesicle; extrinsic component of plasma membrane; and perinuclear region of cytoplasm; PARTICIPATES IN endocytosis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-hydroxypropanoic acid.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
EPS-15-interacting protein 3; epsin-3; FLJ20778; MGC129899
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Epn3 (epsin 3) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Epn3 (epsin 3) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, Panther
Chinchilla lanigera (long-tailed chinchilla):
Epn3 (epsin 3) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
EPN3 (epsin 3) NCBI
Ortholog
Canis lupus familiaris (dog):
EPN3 (epsin 3) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Epn3 (epsin 3) NCBI
Ortholog
Sus scrofa (pig):
EPN3 (epsin 3) HGNC
EggNOG, Ensembl, NCBI, OMA, OrthoDB, Treefam
Other homologs 2
Rattus norvegicus (Norway rat):
Epn1 (Epsin 1) HGNC
OrthoDB
Mus musculus (house mouse):
Epn1 (epsin 1) HGNC
OrthoDB
Canis lupus familiaris (dog):
EPN1 (epsin 1) HGNC
OrthoDB
Sus scrofa (pig):
EPN1 (epsin 1) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Epn3 (epsin 3)
Alliance
DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Mus musculus (house mouse):
Epn3 (epsin 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
epn3b (epsin 3b)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, TreeFam, ZFIN)
Danio rerio (zebrafish):
epn3a (epsin 3a)
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
ENT1
Alliance
DIOPT (OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
epn-1
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
lqf
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
ENT2
Alliance
DIOPT (OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 17 50,532,735 - 50,543,750 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 17 48,610,043 - 48,621,111 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 17 45,965,047 - 45,976,110 (+) NCBI NCBI36 hg18 NCBI36 Build 34 17 45,965,097 - 45,975,160 NCBI Celera 17 45,071,411 - 45,082,475 (+) NCBI Cytogenetic Map 17 q21.33 NCBI HuRef 17 43,978,042 - 43,989,066 (+) NCBI HuRef CHM1_1 17 48,673,927 - 48,684,990 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol increases expression ISO RGD:1306416 6480464 Ethinyl Estradiol results in increased expression of EPN3 mRNA CTD PMID:17557909 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of EPN3 mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of EPN3 mRNA CTD PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of EPN3 mRNA CTD PMID:23152189 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1315017 6480464 Tetrachlorodibenzodioxin affects the expression of EPN3 mRNA CTD PMID:21570461 2-hydroxypropanoic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of EPN3 mRNA CTD PMID:30851411 4,4'-sulfonyldiphenol increases expression ISO RGD:1315017 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of EPN3 mRNA CTD PMID:30951980 6-propyl-2-thiouracil decreases expression ISO RGD:1306416 6480464 Propylthiouracil results in decreased expression of EPN3 mRNA CTD PMID:24780913 , PMID:25825206 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of EPN3 mRNA CTD PMID:21641981 benzo[a]pyrene decreases expression ISO RGD:1306416 6480464 Benzo(a)pyrene results in decreased expression of EPN3 mRNA CTD PMID:21839799 benzo[a]pyrene increases expression ISO RGD:1315017 6480464 Benzo(a)pyrene results in increased expression of EPN3 mRNA CTD PMID:27195522 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of EPN3 mRNA CTD PMID:21632981 benzo[a]pyrene decreases expression ISO RGD:1315017 6480464 Benzo(a)pyrene results in decreased expression of EPN3 mRNA CTD PMID:22228805 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of EPN3 mRNA CTD PMID:31163220 bisphenol A decreases expression ISO RGD:1306416 6480464 bisphenol A results in decreased expression of EPN3 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:1315017 6480464 bisphenol F results in increased expression of EPN3 mRNA CTD PMID:30951980 carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of EPN3 mRNA CTD PMID:24752500 , PMID:25979313 cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of EPN3 mRNA CTD PMID:27392435 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of EPN3 mRNA CTD PMID:27392435 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of EPN3 mRNA CTD PMID:19549813 diclofenac affects expression EXP 6480464 Diclofenac affects the expression of EPN3 mRNA CTD PMID:24752500 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 endosulfan decreases expression ISO RGD:1306416 6480464 Endosulfan results in decreased expression of EPN3 mRNA CTD PMID:29391264 furan increases expression ISO RGD:1306416 6480464 furan results in increased expression of EPN3 mRNA CTD PMID:27387713 glycidol increases expression ISO RGD:1306416 6480464 glycidol results in increased expression of EPN3 mRNA CTD PMID:24395379 hexane decreases methylation ISO RGD:1306416 6480464 n-hexane results in decreased methylation of EPN3 promoter CTD PMID:23740543 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of EPN3 mRNA CTD PMID:20044591 menadione affects expression EXP 6480464 Vitamin K 3 affects the expression of EPN3 mRNA CTD PMID:20044591 mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of EPN3 mRNA CTD PMID:26272509 mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPN3 mRNA CTD PMID:27188386 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of EPN3 mRNA CTD PMID:16510598 panobinostat multiple interactions EXP 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPN3 mRNA CTD PMID:27188386 paracetamol affects expression ISO RGD:1315017 6480464 Acetaminophen affects the expression of EPN3 mRNA CTD PMID:17562736 phenethyl isothiocyanate increases expression ISO RGD:1306416 6480464 phenethyl isothiocyanate results in increased expression of EPN3 mRNA CTD PMID:17616710 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of EPN3 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPN3 mRNA CTD PMID:27188386 propanal increases expression EXP 6480464 propionaldehyde results in increased expression of EPN3 mRNA CTD PMID:26079696 quercetin increases expression EXP 6480464 Quercetin results in increased expression of EPN3 mRNA CTD PMID:21632981 rac-lactic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of EPN3 mRNA CTD PMID:30851411 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide affects expression EXP 6480464 Silicon Dioxide analog affects the expression of EPN3 mRNA CTD PMID:25895662 Tesaglitazar increases expression ISO RGD:1306416 6480464 tesaglitazar results in increased expression of EPN3 mRNA CTD PMID:21515302 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of EPN3 mRNA CTD PMID:24935251 troglitazone increases expression ISO RGD:1306416 6480464 troglitazone results in increased expression of EPN3 mRNA CTD PMID:21515302 urethane decreases expression EXP 6480464 Urethane results in decreased expression of EPN3 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1315017 6480464 Valproic Acid affects the expression of EPN3 mRNA CTD PMID:17292431 valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPN3 mRNA CTD PMID:27188386 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of EPN3 mRNA CTD PMID:23179753 more ... valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of EPN3 mRNA CTD PMID:25979313 vinclozolin decreases expression ISO RGD:1306416 6480464 vinclozolin results in decreased expression of EPN3 mRNA CTD PMID:23034163 zearalenone decreases expression EXP 6480464 Zearalenone results in decreased expression of EPN3 mRNA CTD PMID:19371625 
Gene-Chemical Interaction Annotations
