Gene: DHCR24 (24-dehydrocholesterol reductase) Homo sapiens
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Symbol: DHCR24
Name: 24-dehydrocholesterol reductase
Description: This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24-reductase; DCE; delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; diminuto/dwarf1 homolog; KIAA0018; Nbla03646; seladin 1; seladin-1; SELADIN1; selective AD indicator 1
Orthologs:
Mus musculus (house mouse) : Dhcr24 (24-dehydrocholesterol reductase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dhcr24 (24-dehydrocholesterol reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhcr24 (24-dehydrocholesterol reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : DHCR24 (24-dehydrocholesterol reductase)
Canis lupus familiaris (dog) : DHCR24 (24-dehydrocholesterol reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhcr24 (24-dehydrocholesterol reductase)
Sus scrofa (pig) : DHCR24 (24-dehydrocholesterol reductase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38154,849,627 - 54,887,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37155,315,300 - 55,352,921 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,087,888 - 55,125,509 (-)NCBINCBI36hg18NCBI36
Build 34155,027,320 - 55,064,926NCBI
Celera153,602,965 - 53,640,513 (-)NCBI
Cytogenetic Map1p32.3NCBI
HuRef153,429,205 - 53,466,807 (-)NCBIHuRef
CHM1_1155,431,045 - 55,468,571 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DHCR24
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315197
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-05-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.