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Gene: VPS28 (VPS28 subunit of ESCRT-I) Homo sapiens
Symbol: VPS28
Name: VPS28 subunit of ESCRT-I
Description: Exhibits ubiquitin binding activity. Involved in positive regulation of ubiquitin-dependent endocytosis; regulation of protein metabolic process; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Localizes to cytosol; endosome; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ESCRT-I complex subunit VPS28; H-Vps28; MGC60323; vacuolar protein sorting 28 (yeast); vacuolar protein sorting 28 homolog; vacuolar protein sorting-associated protein 28 homolog; VPS28, ESCRT-I subunit; yeast class E protein Vps28p homolog
Mus musculus (house mouse) : Vps28 (vacuolar protein sorting 28)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vps28 (VPS28 subunit of ESCRT-I)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vps28 (VPS28 subunit of ESCRT-I)
Pan paniscus (bonobo/pygmy chimpanzee) : VPS28 (VPS28 subunit of ESCRT-I)
Canis lupus familiaris (dog) : VPS28 (VPS28 subunit of ESCRT-I)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vps28 (VPS28 subunit of ESCRT-I)
Sus scrofa (pig) : VPS28 (VPS28 subunit of ESCRT-I)
Chlorocebus sabaeus (African green monkey) : VPS28 (VPS28 subunit of ESCRT-I)
Heterocephalus glaber (naked mole-rat) : Vps28 (VPS28 subunit of ESCRT-I)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8144,423,601 - 144,428,563 (-)EnsemblGRCh38hg38GRCh38
GRCh388144,423,601 - 144,428,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,648,984 - 145,653,946 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,619,808 - 145,624,735 (-)NCBINCBI36hg18NCBI36
Build 348145,619,807 - 145,624,735NCBI
Celera8141,823,433 - 141,828,362 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,762,216 - 140,767,180 (-)NCBIHuRef
CHM1_18145,687,291 - 145,692,187 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on VPS28
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315210
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.