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Gene: CLIC2 (chloride intracellular channel 2) Homo sapiens
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Symbol: CLIC2
Name: chloride intracellular channel 2
Description: This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride intracellular channel protein 2; CLCNL2; CLIC2b; MRXS32; XAP121
Orthologs:
Rattus norvegicus (Norway rat) : Clic2 (chloride intracellular channel 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clic2 (chloride intracellular channel 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CLIC2 (chloride intracellular channel 2)
Canis lupus familiaris (dog) : CLIC2 (chloride intracellular channel 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clic2 (chloride intracellular channel 2)
Sus scrofa (pig) : CLIC2 (chloride intracellular channel 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X155,276,207 - 155,334,681 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X154,505,500 - 154,563,997 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X154,158,694 - 154,217,180 (-)NCBINCBI36hg18NCBI36
Build 34X154,070,159 - 154,127,661NCBI
CeleraX154,664,011 - 154,722,432 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX143,049,088 - 143,107,752 (-)NCBIHuRef
CHM1_1X154,416,158 - 154,475,626 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CLIC2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315278
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.