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Gene: LAMC2 (laminin subunit gamma 2) Homo sapiens
Symbol: LAMC2
Name: laminin subunit gamma 2
Description: Predicted to have extracellular matrix structural constituent and heparin binding activity. Involved in positive regulation of cell migration and positive regulation of cell population proliferation. Localizes to the collagen-containing extracellular matrix. Implicated in junctional epidermolysis bullosa; junctional epidermolysis bullosa Herlitz type; junctional epidermolysis bullosa non-Herlitz type; and lung small cell carcinoma. Biomarker of lung non-small cell carcinoma and lung squamous cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alternatively spliced laminin gamma2 chain; B2T; BM600; BM600-100kDa; cell-scattering factor 140 kDa subunit; CSF; CSF 140 kDa subunit; EBR2; EBR2A; epiligrin subunit gamma; kalinin (105kD); kalinin subunit gamma; kalinin-105kDa; ladsin (140kDa); ladsin 140 kDa subunit; LAMB2T; laminin B2t chain; laminin subunit gamma-2; laminin, gamma 2; laminin-5 subunit gamma; LAMNB2; large adhesive scatter factor 140 kDa subunit; MGC138491; MGC141938; nicein (100kDa); nicein subunit gamma; nicein-100kDa
Mus musculus (house mouse) : Lamc2 (laminin, gamma 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lamc2 (laminin subunit gamma 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lamc2 (laminin subunit gamma 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LAMC2 (laminin subunit gamma 2)
Canis lupus familiaris (dog) : LAMC2 (laminin subunit gamma 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lamc2 (laminin subunit gamma 2)
Sus scrofa (pig) : LAMC2 (laminin subunit gamma 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1183,186,238 - 183,245,127 (+)Ensembl
GRCh381183,186,264 - 183,245,127 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371183,147,952 - 183,214,262 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,421,797 - 181,480,885 (+)NCBINCBI36hg18NCBI36
Celera1156,266,276 - 156,325,361 (+)NCBI
Cytogenetic Map1q25.3NCBI
HuRef1154,390,994 - 154,450,096 (+)NCBIHuRef
CHM1_11184,578,284 - 184,637,373 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LAMC2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315384
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.