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Gene: CHUK (component of inhibitor of nuclear factor kappa B kinase complex) Homo sapiens
Symbol: CHUK
Name: component of inhibitor of nuclear factor kappa B kinase complex
CRRD ID: 1315401
Description: Exhibits several functions, including protein dimerization activity; scaffold protein binding activity; and transferrin receptor binding activity. Predicted to contribute to IkappaB kinase activity. Involved in several processes, including intracellular signal transduction; positive regulation of I-kappaB kinase/NF-kappaB signaling; and regulation of gene expression. Localizes to cytosol and nucleoplasm. Implicated in cocoon syndrome and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: conserved helix-loop ubiquitous kinase; conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; ikappaB kinase; IkB kinase alpha subunit; IKBKA; IKK-a kinase; IKK-alpha; IKK1; IKKA; inhibitor of nuclear factor kappa-B kinase subunit alpha; NFKBIKA; nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; TCF16; transcription factor 16
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl10100,188,300 - 100,229,596 (-)EnsemblGRCh38hg38GRCh38
GRCh3810100,188,300 - 100,229,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710101,948,123 - 101,989,367 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,938,114 - 101,979,334 (-)NCBINCBI36hg18NCBI36
Build 3410101,938,114 - 101,979,366NCBI
Celera1095,686,067 - 95,727,300 (-)NCBI
Cytogenetic Map10q24.31NCBI
HuRef1095,577,055 - 95,618,304 (-)NCBIHuRef
CHM1_110102,232,742 - 102,274,060 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CHUK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315401
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.