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Gene: Chuk (conserved helix-loop-helix ubiquitous kinase) Mus musculus
Symbol: Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Description: Exhibits protein kinase activity. Predicted to contribute to IkappaB kinase activity. Involved in several processes, including mammary gland development; positive regulation of cell communication; and response to virus. Localizes to CD40 receptor complex and cytoplasmic side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb. Used to study cocoon syndrome. Human ortholog(s) of this gene implicated in cocoon syndrome and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH 1,4-dithiothreitol; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI256658; Chuk1; Fbx24; Fbxo24; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase alpha; IkappaB kinase alpha; IKBKA; IKK alpha; IKK-A; IKK1; Ikka; inhibitor of nuclear factor kappa-B kinase subunit alpha; MGC25325; NFKBIKA; nuclear factor NF-kappa-B inhibitor kinase alpha
Related Pseudogenes: Gm17809  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1944,073,335 - 44,107,480 (-)EnsemblGRCm38mm10GRCm38
GRCm381944,073,334 - 44,107,505 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371944,147,824 - 44,181,967 (-)NCBIGRCm37mm9NCBIm37
MGSCv361944,126,647 - 44,160,756 (-)NCBImm8
Celera1944,858,810 - 44,892,945 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Chuk
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315402
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.