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Gene: Prkra (protein kinase, interferon inducible double stranded RNA dependent activator) Mus musculus
Symbol: Prkra
Name: protein kinase, interferon inducible double stranded RNA dependent activator
Description: Predicted to have RNA binding activity; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including cellular response to oxidative stress; ear morphogenesis; and positive regulation of intrinsic apoptotic signaling pathway. Predicted to localize to the RISC-loading complex; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia 16. Is expressed in several structures, including 4-cell stage embryo; central nervous system; olfactory epithelium; and retina. Orthologous to human PRKRA (protein activator of interferon induced protein kinase EIF2AK2); PARTICIPATES IN ceramide signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AV120107; interferon-inducible double stranded RNA-dependent protein kinase activator A; interferon-inducible double-stranded RNA-dependent protein kinase activator A; lear; Pact; PKR-associated protein X; PKR-associating protein X; PRK; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA-dependent activator; protein kinase, interferon-inducible double-stranded RNA-dependent activator; RAX
Related Pseudogenes: Gm19212  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38276,609,215 - 76,648,220 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37276,467,994 - 76,486,051 (-)NCBIGRCm37mm9NCBIm37
MGSCv36276,430,776 - 76,448,833 (-)NCBImm8
Celera278,291,609 - 78,309,670 (-)NCBICelera
Cytogenetic Map2 C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prkra
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315477
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.