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Gene: NKX1-2 (NK1 homeobox 2) Homo sapiens
Symbol: NKX1-2
Name: NK1 homeobox 2
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin; INTERACTS WITH 17beta-estradiol; aflatoxin B1; aflatoxin B2.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bB238F13.2; C10orf121; homeobox protein SAX-1; NK1 transcription factor related, locus 2; NK1 transcription factor-related protein 2; NKX-1.1; Sax1-like
Mus musculus (house mouse) : Nkx1-2 (NK1 homeobox 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nkx1-2 (NK1 homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx1-2 (NK1 homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX1-2 (NK1 homeobox 2)
Canis lupus familiaris (dog) : NKX1-2 (NK1 homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx1-2 (NK1 homeobox 2)
Sus scrofa (pig) : NKX1-2 (NK1 homeobox 2)
Chlorocebus sabaeus (African green monkey) : NKX1-2 (NK1 homeobox 2)
Heterocephalus glaber (naked mole-rat) : Nkx1-2 (NK1 homeobox 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10124,445,243 - 124,450,035 (-)EnsemblGRCh38hg38GRCh38
GRCh3810124,445,243 - 124,450,035 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710126,135,998 - 126,138,550 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610126,125,988 - 126,128,534 (-)NCBINCBI36hg18NCBI36
Celera10119,908,245 - 119,910,797 (-)NCBI
Cytogenetic Map10q26.13NCBI
HuRef10119,820,731 - 119,823,283 (-)NCBIHuRef
CHM1_110126,417,943 - 126,420,495 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NKX1-2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315537
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.