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Gene: DENND5A (DENN domain containing 5A) Homo sapiens
Symbol: DENND5A
Name: DENN domain containing 5A
Description: Exhibits Rab guanyl-nucleotide exchange factor activity. Involved in retrograde transport, endosome to Golgi. Localizes to the trans-Golgi network. Colocalizes with the retromer complex. Implicated in early infantile epileptic encephalopathy 49.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DENN domain-containing protein 5A; DENN/MADD domain containing 5A; EIEE49; FLJ22354; FLJ33829; FLJ43455; KIAA1091; RAB6 interacting protein 1; rab6-interacting protein 1; RAB6IP1
Mus musculus (house mouse) : Dennd5a (DENN/MADD domain containing 5A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dennd5a (DENN domain containing 5A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dennd5a (DENN domain containing 5A)
Pan paniscus (bonobo/pygmy chimpanzee) : DENND5A (DENN domain containing 5A)
Canis lupus familiaris (dog) : DENND5A (DENN domain containing 5A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dennd5a (DENN domain containing 5A)
Sus scrofa (pig) : DENND5A (DENN domain containing 5A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38119,138,825 - 9,265,350 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37119,160,372 - 9,286,882 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,116,948 - 9,243,447 (-)NCBINCBI36hg18NCBI36
Build 34119,116,952 - 9,243,447NCBI
Celera119,282,225 - 9,408,081 (-)NCBI
Cytogenetic Map11p15.4NCBI
HuRef118,832,931 - 8,959,599 (-)NCBIHuRef
CHM1_1119,159,270 - 9,285,849 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DENND5A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315561
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.