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Gene: DNA2 (DNA replication helicase/nuclease 2) Homo sapiens
Symbol: DNA2
Name: DNA replication helicase/nuclease 2
Description: Exhibits DNA binding activity; DNA helicase activity; and endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; DNA replication checkpoint; and mitochondrial DNA replication. Localizes to mitochondrial nucleoid and nucleoplasm. Colocalizes with gamma DNA polymerase complex. Implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA2 (DNA replication helicase, yeast, homolog)-like; DNA2 DNA replication helicase 2-like; DNA2-like helicase; DNA2L; FLJ10063; hDNA2; KIAA0083; MGC133297; PEOA6; SCKL8
Mus musculus (house mouse) : Dna2 (DNA replication helicase/nuclease 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dna2 (DNA replication helicase/nuclease 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DNA2 (DNA replication helicase/nuclease 2)
Canis lupus familiaris (dog) : DNA2 (DNA replication helicase/nuclease 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dna2 (DNA replication helicase/nuclease 2)
Sus scrofa (pig) : DNA2 (DNA replication helicase/nuclease 2)
Chlorocebus sabaeus (African green monkey) : DNA2 (DNA replication helicase/nuclease 2)
Heterocephalus glaber (naked mole-rat) : Dna2 (DNA replication helicase/nuclease 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1068,414,064 - 68,472,121 (-)EnsemblGRCh38hg38GRCh38
GRCh381068,414,064 - 68,472,521 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371070,173,821 - 70,231,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,843,827 - 69,901,885 (-)NCBINCBI36hg18NCBI36
Build 341069,843,827 - 69,901,678NCBI
Celera1063,449,181 - 63,507,264 (-)NCBI
Cytogenetic Map10q21.3NCBI
HuRef1064,173,263 - 64,231,457 (-)NCBIHuRef
CHM1_11070,455,594 - 70,514,126 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DNA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315606
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.