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Gene: XRCC3 (X-ray repair cross complementing 3) Homo sapiens
Symbol: XRCC3
Name: X-ray repair cross complementing 3
Description: Contributes to crossover junction endodeoxyribonuclease activity and four-way junction DNA binding activity. Involved in DNA metabolic process and regulation of cell cycle process. Localizes to several cellular components, including the nucleus; perinuclear region of cytoplasm; and replication fork. Implicated in breast cancer; familial melanoma; and pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMM6; DNA repair protein XRCC3; RAD51-like; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross-complementing protein 3
Mus musculus (house mouse) : Xrcc3 (X-ray repair complementing defective repair in Chinese hamster cells 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xrcc3 (X-ray repair cross complementing 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrcc3 (X-ray repair cross complementing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : XRCC3 (X-ray repair cross complementing 3)
Canis lupus familiaris (dog) : XRCC3 (X-ray repair cross complementing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrcc3 (X-ray repair cross complementing 3)
Sus scrofa (pig) : XRCC3 (X-ray repair cross complementing 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3814103,697,611 - 103,715,486 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714104,163,945 - 104,181,823 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614103,233,707 - 103,251,576 (-)NCBINCBI36hg18NCBI36
Build 3414103,233,707 - 103,251,549NCBI
Celera1484,218,198 - 84,236,079 (-)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1484,342,246 - 84,360,133 (-)NCBIHuRef
CHM1_114104,102,095 - 104,119,977 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on XRCC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315699
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.