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Gene: XRCC3 (X-ray repair cross complementing 3) Homo sapiens
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Symbol: XRCC3
Name: X-ray repair cross complementing 3
Description: Contributes to crossover junction endodeoxyribonuclease activity and four-way junction DNA binding activity. Involved in DNA metabolic process and regulation of cell cycle process. Localizes to several cellular components, including the nucleus; perinuclear region of cytoplasm; and replication fork. Implicated in breast cancer; familial melanoma; and pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMM6; DNA repair protein XRCC3; RAD51-like; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross-complementing protein 3
Orthologs:
Mus musculus (house mouse) : Xrcc3 (X-ray repair complementing defective repair in Chinese hamster cells 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xrcc3 (X-ray repair cross complementing 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrcc3 (X-ray repair cross complementing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : XRCC3 (X-ray repair cross complementing 3)
Canis lupus familiaris (dog) : XRCC3 (X-ray repair cross complementing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrcc3 (X-ray repair cross complementing 3)
Sus scrofa (pig) : XRCC3 (X-ray repair cross complementing 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814103,697,611 - 103,715,486 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714104,163,945 - 104,181,823 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614103,233,707 - 103,251,576 (-)NCBINCBI36hg18NCBI36
Build 3414103,233,707 - 103,251,549NCBI
Celera1484,218,198 - 84,236,079 (-)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1484,342,246 - 84,360,133 (-)NCBIHuRef
CHM1_114104,102,095 - 104,119,977 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on XRCC3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315699
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.