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Gene: Ercc1 (excision repair cross-complementing rodent repair deficiency, complementation group 1) Mus musculus
Symbol: Ercc1
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1
Description: Exhibits TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in several processes, including DNA metabolic process; gamete generation; and positive regulation of nucleobase-containing compound metabolic process. Predicted to localize to nucleus. Used to study XFE progeroid syndrome. Human ortholog(s) of this gene implicated in several diseases, including bone cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); kidney failure; and transient cerebral ischemia. Is expressed in brain; cerebral cortex; and telencephalon. Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit); PARTICIPATES IN nucleotide excision repair pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol; 1H-pyrazole.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA excision repair protein ERCC-1; Ercc-1; excision repair 1
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl719,344,778 - 19,356,524 (+)EnsemblGRCm38mm10GRCm38
GRCm38719,344,067 - 19,356,524 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37719,930,420 - 19,941,873 (+)NCBIGRCm37mm9NCBIm37
MGSCv36718,503,628 - 18,515,044 (+)NCBImm8
Celera716,751,825 - 16,763,278 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ercc1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315922
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.