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Gene: PSME3 (proteasome activator subunit 3) Homo sapiens
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Symbol: PSME3
Name: proteasome activator subunit 3
Description: Exhibits several functions, including MDM2/MDM4 family protein binding activity; endopeptidase activator activity; and p53 binding activity. Involved in negative regulation of extrinsic apoptotic signaling pathway and regulation of proteasomal protein catabolic process. Localizes to the cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 11S regulator complex gamma subunit; 11S regulator complex subunit gamma; activator of multicatalytic protease subunit 3; epididymis secretory protein Li 283; HEL-S-283; Ki; Ki antigen; Ki nuclear autoantigen; PA28 gamma variant 5; PA28-gamma; PA28G; PA28gamma; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki); proteasome activator 28 subunit gamma; proteasome activator 28-gamma; proteasome activator complex subunit 3; REG gamma-3; REG-GAMMA
Orthologs:
Mus musculus (house mouse) : Psme3 (proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki))  MGI  Alliance
Rattus norvegicus (Norway rat) : Psme3 (proteasome activator subunit 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psme3 (proteasome activator subunit 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PSME3 (proteasome activator subunit 3)
Canis lupus familiaris (dog) : PSME3 (proteasome activator subunit 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psme3 (proteasome activator subunit 3)
Sus scrofa (pig) : PSME3 (proteasome activator subunit 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,833,397 - 42,843,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,985,159 - 40,995,777 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,238,949 - 38,249,303 (+)NCBINCBI36hg18NCBI36
Build 341738,238,948 - 38,249,301NCBI
Celera1737,641,478 - 37,651,832 (+)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1736,749,623 - 36,760,415 (+)NCBIHuRef
CHM1_11741,220,772 - 41,231,390 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PSME3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315927
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.