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Gene: PSME3 (proteasome activator subunit 3) Homo sapiens
Symbol: PSME3
Name: proteasome activator subunit 3
Description: Exhibits several functions, including MDM2/MDM4 family protein binding activity; endopeptidase activator activity; and p53 binding activity. Involved in negative regulation of extrinsic apoptotic signaling pathway and regulation of proteasomal protein catabolic process. Localizes to the cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 11S regulator complex gamma subunit; 11S regulator complex subunit gamma; activator of multicatalytic protease subunit 3; epididymis secretory protein Li 283; HEL-S-283; Ki; Ki antigen; Ki nuclear autoantigen; PA28 gamma variant 5; PA28-gamma; PA28G; PA28gamma; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki); proteasome activator 28 subunit gamma; proteasome activator 28-gamma; proteasome activator complex subunit 3; REG gamma-3; REG-GAMMA
Mus musculus (house mouse) : Psme3 (proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki))  MGI  Alliance
Rattus norvegicus (Norway rat) : Psme3 (proteasome activator subunit 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psme3 (proteasome activator subunit 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PSME3 (proteasome activator subunit 3)
Canis lupus familiaris (dog) : PSME3 (proteasome activator subunit 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psme3 (proteasome activator subunit 3)
Sus scrofa (pig) : PSME3 (proteasome activator subunit 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381742,833,397 - 42,843,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,985,159 - 40,995,777 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,238,949 - 38,249,303 (+)NCBINCBI36hg18NCBI36
Build 341738,238,948 - 38,249,301NCBI
Celera1737,641,478 - 37,651,832 (+)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1736,749,623 - 36,760,415 (+)NCBIHuRef
CHM1_11741,220,772 - 41,231,390 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PSME3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1315927
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.