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Gene: TP73 (tumor protein p73) Homo sapiens
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Symbol: TP73
Name: tumor protein p73
CRRD ID: 1316062
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and p53 binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of cardiac muscle cell proliferation; and positive regulation of cell cycle arrest. Localizes to Golgi apparatus; cell junction; and nucleoplasm. Implicated in breast cancer; lung cancer; nephroblastoma; and renal cell carcinoma. Biomarker of breast cancer (multiple); cervix uteri carcinoma in situ; prostate disease (multiple); transitional cell carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: p53-like transcription factor; p53-related protein; P73
Orthologs:
Mus musculus (house mouse) : Trp73 (transformation related protein 73)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tp73 (tumor protein p73)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp73 (tumor protein p73)
Pan paniscus (bonobo/pygmy chimpanzee) : TP73 (tumor protein p73)
Canis lupus familiaris (dog) : TP73 (tumor protein p73)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp73 (tumor protein p73)
Sus scrofa (pig) : TP73 (tumor protein p73)
Chlorocebus sabaeus (African green monkey) : TP73 (tumor protein p73)
Heterocephalus glaber (naked mole-rat) : Tp73 (tumor protein p73)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl13,652,516 - 3,736,201 (+)EnsemblGRCh38hg38GRCh38
GRCh3813,652,516 - 3,736,201 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713,569,129 - 3,652,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613,558,989 - 3,639,716 (+)NCBINCBI36hg18NCBI36
Build 3413,592,285 - 3,673,013NCBI
Celera12,823,557 - 2,904,508 (+)NCBI
Cytogenetic Map1p36.32NCBI
HuRef12,864,839 - 2,947,956 (+)NCBIHuRef
CHM1_113,555,405 - 3,639,797 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TP73
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316062
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.