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Gene: TP73 (tumor protein p73) Homo sapiens
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Symbol: TP73
Name: tumor protein p73
Description: This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: p53-like transcription factor; p53-related protein; P73
Orthologs:
Mus musculus (house mouse) : Trp73 (transformation related protein 73)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tp73 (tumor protein p73)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp73 (tumor protein p73)
Pan paniscus (bonobo/pygmy chimpanzee) : TP73 (tumor protein p73)
Canis lupus familiaris (dog) : TP73 (tumor protein p73)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp73 (tumor protein p73)
Sus scrofa (pig) : TP73 (tumor protein p73)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813,652,565 - 3,736,201 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713,569,129 - 3,652,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613,558,989 - 3,639,716 (+)NCBINCBI36hg18NCBI36
Build 3413,592,285 - 3,673,013NCBI
Celera12,823,557 - 2,904,508 (+)NCBI
Cytogenetic Map1p36.32NCBI
HuRef12,864,839 - 2,947,956 (+)NCBIHuRef
CHM1_113,555,405 - 3,639,797 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TP73
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316062
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.