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Gene: WDFY3 (WD repeat and FYVE domain containing 3) Homo sapiens
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Symbol: WDFY3
Name: WD repeat and FYVE domain containing 3
Description: Exhibits 1-phosphatidylinositol binding activity. Involved in aggrephagy. Localizes to several cellular components, including the extrinsic component of membrane; inclusion body; and nucleus. Colocalizes with the Atg12-Atg5-Atg16 complex and autophagosome. Implicated in primary autosomal dominant microcephaly 18.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALFY; autophagy-linked FYVE protein; BCHS; KIAA0993; MCPH18; MGC16461; WD repeat and FYVE domain-containing protein 3; ZFYVE25
Orthologs:
Mus musculus (house mouse) : Wdfy3 (WD repeat and FYVE domain containing 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Wdfy3 (WD repeat and FYVE domain containing 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wdfy3 (WD repeat and FYVE domain containing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : WDFY3 (WD repeat and FYVE domain containing 3)
Canis lupus familiaris (dog) : WDFY3 (WD repeat and FYVE domain containing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wdfy3 (WD repeat and FYVE domain containing 3)
Sus scrofa (pig) : WDFY3 (WD repeat and FYVE domain containing 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38484,669,547 - 84,966,690 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37485,590,690 - 85,887,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36485,809,719 - 86,106,568 (-)NCBINCBI36hg18NCBI36
Celera482,881,176 - 83,177,858 (-)NCBI
Cytogenetic Map4q21.23NCBI
HuRef481,332,682 - 81,629,739 (-)NCBIHuRef
CHM1_1485,567,640 - 85,864,722 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on WDFY3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316086
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.