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Gene: WDFY3 (WD repeat and FYVE domain containing 3) Homo sapiens
Symbol: WDFY3
Name: WD repeat and FYVE domain containing 3
Description: Exhibits 1-phosphatidylinositol binding activity. Involved in aggrephagy. Localizes to several cellular components, including the extrinsic component of membrane; inclusion body; and nucleus. Colocalizes with the Atg12-Atg5-Atg16 complex and autophagosome. Implicated in primary autosomal dominant microcephaly 18.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALFY; autophagy-linked FYVE protein; BCHS; KIAA0993; MCPH18; MGC16461; WD repeat and FYVE domain-containing protein 3; ZFYVE25
Mus musculus (house mouse) : Wdfy3 (WD repeat and FYVE domain containing 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Wdfy3 (WD repeat and FYVE domain containing 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wdfy3 (WD repeat and FYVE domain containing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : WDFY3 (WD repeat and FYVE domain containing 3)
Canis lupus familiaris (dog) : WDFY3 (WD repeat and FYVE domain containing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wdfy3 (WD repeat and FYVE domain containing 3)
Sus scrofa (pig) : WDFY3 (WD repeat and FYVE domain containing 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38484,669,547 - 84,966,690 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37485,590,690 - 85,887,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36485,809,719 - 86,106,568 (-)NCBINCBI36hg18NCBI36
Celera482,881,176 - 83,177,858 (-)NCBI
Cytogenetic Map4q21.23NCBI
HuRef481,332,682 - 81,629,739 (-)NCBIHuRef
CHM1_1485,567,640 - 85,864,722 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on WDFY3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316086
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.