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Gene: ANKRD27 (ankyrin repeat domain 27) Homo sapiens
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Symbol: ANKRD27
Name: ankyrin repeat domain 27
Description: Exhibits Rab GTPase binding activity and guanyl-nucleotide exchange factor activity. Involved in early endosome to late endosome transport; negative regulation of SNARE complex assembly; and retrograde transport, endosome to plasma membrane. Localizes to the endosome; lysosome; and plasma membrane. Implicated in eosinophilic esophagitis; PARTICIPATES IN retromer-mediated pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B2; antirheumatic drug.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ankyrin repeat domain 27 (VPS9 domain); ankyrin repeat domain-containing protein 27; DKFZP434L0718; FLJ00040; PP12899; VARP; Vps9 domain and ankyrin-repeat-containing protein; VPS9 domain-containing protein; VPS9-ankyrin-repeat protein
Orthologs:
Mus musculus (house mouse) : Ankrd27 (ankyrin repeat domain 27 (VPS9 domain))  MGI  Alliance
Rattus norvegicus (Norway rat) : Ankrd27 (ankyrin repeat domain 27)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ankrd27 (ankyrin repeat domain 27)
Pan paniscus (bonobo/pygmy chimpanzee) : ANKRD27 (ankyrin repeat domain 27)
Canis lupus familiaris (dog) : ANKRD27 (ankyrin repeat domain 27)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ankrd27 (ankyrin repeat domain 27)
Sus scrofa (pig) : ANKRD27 (ankyrin repeat domain 27)
Chlorocebus sabaeus (African green monkey) : ANKRD27 (ankyrin repeat domain 27)
Heterocephalus glaber (naked mole-rat) : Ankrd27 (ankyrin repeat domain 27)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1932,597,006 - 32,676,597 (-)Ensembl
GRCh381932,597,005 - 32,675,215 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371933,087,907 - 33,166,102 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361937,779,747 - 37,857,942 (-)NCBINCBI36hg18NCBI36
Build 341937,779,753 - 37,857,919NCBI
Celera1929,781,556 - 29,859,734 (-)NCBI
Cytogenetic Map19q13.11NCBI
HuRef1929,590,946 - 29,669,349 (-)NCBIHuRef
CHM1_11933,088,999 - 33,167,383 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ANKRD27
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316102
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.