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Gene: CENPE (centromere protein E) Homo sapiens
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Symbol: CENPE
Name: centromere protein E
Description: Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CENP-E; Centromere autoantigen E (312kD); centromere protein E, 312kDa; centromere-associated protein E; KIF10; kinesin family member 10; kinesin-7; kinesin-related protein CENPE; MCPH13; PPP1R61; protein phosphatase 1, regulatory subunit 61
Orthologs:
Mus musculus (house mouse) : Cenpe (centromere protein E)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cenpe (centromere protein E)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cenpe (centromere protein E)
Pan paniscus (bonobo/pygmy chimpanzee) : CENPE (centromere protein E)
Canis lupus familiaris (dog) : CENPE (centromere protein E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cenpe (centromere protein E)
Sus scrofa (pig) : CENPE (centromere protein E)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384103,105,806 - 103,198,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374104,026,963 - 104,119,566 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364104,246,412 - 104,339,015 (-)NCBINCBI36hg18NCBI36
Build 344104,384,807 - 104,477,170NCBI
Celera4101,324,102 - 101,416,733 (-)NCBI
Cytogenetic Map4q24NCBI
HuRef499,760,728 - 99,853,482 (-)NCBIHuRef
CHM1_14104,003,436 - 104,096,014 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CENPE
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316119
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.