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Gene: MS4A12 (membrane spanning 4-domains A12) Homo sapiens
Symbol: MS4A12
Name: membrane spanning 4-domains A12
Description: The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: membrane-spanning 4-domains subfamily A member 12; membrane-spanning 4-domains, subfamily A, member 12; Ms4a10
Mus musculus (house mouse) : Ms4a12 (membrane-spanning 4-domains, subfamily A, member 12)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ms4a12 (membrane spanning 4-domains A12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ms4a12 (membrane spanning 4-domains A12)
Pan paniscus (bonobo/pygmy chimpanzee) : MS4A12 (membrane spanning 4-domains A12)
Canis lupus familiaris (dog) : LOC102154218 (membrane-spanning 4-domains subfamily A member 12-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ms4a12 (membrane spanning 4-domains A12)
Sus scrofa (pig) : MS4A12 (membrane spanning 4-domains A12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381160,492,743 - 60,507,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371160,260,251 - 60,274,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,016,827 - 60,031,479 (+)NCBINCBI36hg18NCBI36
Build 341160,016,826 - 60,031,475NCBI
Celera1157,624,519 - 57,639,170 (+)NCBI
Cytogenetic Map11q12.2NCBI
HuRef1156,606,695 - 56,621,347 (+)NCBIHuRef
CHM1_11160,126,353 - 60,140,977 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MS4A12
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1316189
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.